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Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum.

• Ning Li, Chun-Fu Wu, Xin-yue Xu, Zhen-Yang Liu, Xian Li, Yu Zhao
• European journal of medicinal chemistry
• 2012

Five novel triterpenes were isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum and identified as gypensapogenin A (1), gypensapogenin B (2), gypensapogenin C (3),… (More)

Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.

• Chun-Lin Wang, Jun-yu Wang, +7 authors Yi-Cheng Lu
• Carcinogenesis
• 2014

The mouse double minute 4 (MDM4) oncoprotein may inhibit tumorigenesis by regulating the apoptotic mediator p53. Ubiquitin-specific protease 2a (USP2a) is a deubiquitinating enzyme that protects MDM4… (More)

Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway.

• Feng-tao Liu, Yu-Jie Yang, +8 authors Jian Wang
• Brain research
• 2016

Accumulation of α-synuclein (α-syn) is pivotally implicated in the pathogenesis of Parkinson׳s disease (PD), and enhancing its clearance might be a promising strategy in PD treatment. It has recently… (More)

The transducible TAT-RIZ1-PR protein exerts histone methyltransferase activity and tumor-suppressive functions in human malignant meningiomas.

• Mao-hua Ding, Zhen Wang, +11 authors Wei-lin Jin
• Biomaterials
• 2015

Malignant meningiomas are a rare meningioma subtype and tend to have post-surgical recurrence. Significant endeavors have been taken to identify functional therapeutic targets to halt the growth of… (More)

Associations between cognitive impairment and motor dysfunction in Parkinson's disease

• Yi-xuan Wang, Jue Zhao, +7 authors Jian Wang
• Brain and behavior
• 2017

INTRODUCTION Numerous studies have been carried out to explore the potential association between neurologic deficits and variable clinical manifestations of Parkinson's disease (PD). The aim of our… (More)

Update on Molecular Imaging in Parkinson’s Disease

• Zhen-Yang Liu, Feng-tao Liu, Chuantao Zuo, James B. Koprich, Jian Wang
• Neuroscience Bulletin
• 2017

Advances in radionuclide tracers have allowed for more accurate imaging that reflects the actions of numerous neurotransmitters, energy metabolism utilization, inflammation, and pathological protein… (More)

Depressive Symptoms Are Associated With Color Vision but not Olfactory Function in Patients With Parkinson's Disease.

• Da-ke Li, Feng-tao Liu, +9 authors Jianjun Wu
• The Journal of neuropsychiatry and clinical…
• 2018

Depressive symptoms and sensory dysfunction, such as reduction in visual and olfactory function, are common in Parkinson's disease (PD). Previous studies have suggested that depressive symptoms are… (More)

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