IgT, a primitive immunoglobulin class specialized in mucosal immunity
- Yongan Zhang, I. Salinas, J. Sunyer
- BiologyNature Immunology
- 1 September 2010
It is shown that IgT, an immunoglobulin isotype of unknown function, acts like a mucosal antibody, and detected responses of rainbow trout IgT to an intestinal parasite only in the gut, whereas IgM responses were confined to the serum.
Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution
In vertebrates, the ten well-characterized IRF family members shared a relatively high degree of similarity in genomic structure and syntenic gene arrangement, implying that they might have been evolved in a similar pattern and with similar selective pressure in different classes of vertebrates.
Teleost skin, an ancient mucosal surface that elicits gut-like immune responses
The findings suggest that, regardless of their phylogenetic origin and tissue localization, the chief immunoglobulins of all mucosa-associated lymphoid tissue operate under the guidance of primordially conserved principles.
Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
- Zhen Xu, Fumio Takizawa, J. Sunyer
- BiologyNature Communications
- 12 February 2016
It is demonstrated that following pathogen exposure, IgT+ B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species.
Novel Teleost CD4-Bearing Cell Populations Provide Insights into the Evolutionary Origins and Primordial Roles of CD4+ Lymphocytes and CD4+ Macrophages
- Fumio Takizawa, S. Magadán, J. Sunyer
- BiologyJournal of Immunology
- 4 May 2016
This study fills in an important gap in the knowledge of teleost CD4-bearing leukocytes, thus revealing critical insights into the evolutionary origins and primordial roles of CD4+ lymphocytes andCD4+ monocytes/macrophages.
Current use and development of fish vaccines in China.
- Qingchao Wang, W. Ji, Zhen Xu
- BiologyFish and Shellfish Immunology
- 7 December 2019
Polymeric immunoglobulin receptor in dojo loach (Misgurnus anguillicaudatus): Molecular characterization and expression analysis in response to bacterial and parasitic challenge
- Yong-yao Yu, Yangzhou Liu, Zhen Xu
- BiologyFish and Shellfish Immunology
- 1 February 2018
Immune responses of fish to Ichthyophthirius multifiliis (Ich): A model for understanding immunity against protozoan parasites.
- Qingchao Wang, Yong-yao Yu, Xiao-ting Zhang, Zhen Xu
- Biology, Environmental ScienceDevelopmental and Comparative Immunology
- 1 April 2019
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