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We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between(More)
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a(More)
We deal with embedding a large scale knowledge graph composed of entities and relations into a continuous vector space. TransE is a promising method proposed recently, which is very efficient while achieving state-of-the-art predictive performance. We discuss some mapping properties of relations which should be considered in embedding, such as reflexive ,(More)
We examine the embedding approach to reason new relational facts from a large-scale knowledge graph and a text corpus. We propose a novel method of jointly embedding entities and words into the same continuous vector space. The embedding process attempts to preserve the relations between entities in the knowledge graph and the concurrences of words in the(More)
SUMMARY We study different variants of the augmented Lagrangian-based block triangular preconditioner introduced by the first two authors in [SIAM J. The preconditioners are used to accelerate the convergence of the Generalized Minimal Residual (GMRES) method applied to various finite element and MAC discretizations of the Oseen problem in two and three(More)
BACKGROUND The 10-item Perceived Stress Scale (PSS-10) is one of most widely used instruments to measure a global level of perceived stress in a range of clinical and research settings. This study was conducted to examine the psychometric properties of the Simplified Chinese version of the PSS-10 in policewomen. METHODOLOGY A total of 240 policewomen were(More)
BACKGROUND The advent of genomics-based technologies has revolutionized many fields of biological enquiry. However, chromosome walking or flanking sequence cloning is still a necessary and important procedure to determining gene structure. Such methods are used to identify T-DNA insertion sites and so are especially relevant for organisms where large T-DNA(More)
This study used resting-state functional magnetic resonance imaging (fMRI) to investigate whether functional connectivity is altered in people developing post-traumatic stress disorder (PTSD) following recent trauma. Sixty-two participants who had experienced recent acute traumatic events underwent a 7.3 min resting fMRI scan within 2 days post accident. Of(More)
Ganoderma lucidum is a widely used medicinal macrofungus in traditional Chinese medicine that creates a diverse set of bioactive compounds. Here we report its 43.3-Mb genome, encoding 16,113 predicted genes, obtained using next-generation sequencing and optical mapping approaches. The sequence analysis reveals an impressive array of genes encoding(More)