Learn More
Parkinson's disease, schizophrenia, Huntington's chorea and drug addiction are manifestations of malfunctioning neurons within the striatum region at the base of the human forebrain. A key component of these neurons is the protein DARPP-32, which receives and processes various types of dopamine and glutamate inputs and translates them into specific(More)
This paper proposes a trajectory tracking scheme which belongs to the sliding mode control (SMC) for the 4-degree-of-freedom (DOF) parallel robots. Two fuzzy logic systems (FLS) are first put forward to replace the constant switching control gain and the width of the boundary layer. The fuzzy adaptive supervisory controller (FASC) is combined with the fuzzy(More)
Several years ago, the "neurochemical mobile" was introduced as a visual tool for explaining the different balances between neurotransmitters in the brain and their role in mental disorders. Here we complement this concept with a non-linear computational systems model representing the direct and indirect interactions between neurotransmitters, as they have(More)
Pesticides, such as rotenone and paraquat, are suspected in the pathogenesis of Parkinson's disease (PD), whose hallmark is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Thus, compounds expected to play a role in the pathogenesis of PD will likely impact the function of dopaminergic neurons. To explore the relationship(More)
Several lines of evidence implicate altered dopamine neurotransmission in schizophrenia. Current drugs for schizophrenia focus on postsynaptic sites of the dopamine signaling pathways, but do not target presynaptic dopamine metabolism. We have begun to develop a mathematical model of dopamine homeostasis, which will aid our understanding of how genetic,(More)
Two grand challenges have been declared as premier goals of computational systems biology. The first is the discovery of network motifs and design principles that help us understand and rationalize why biological systems are organized in the manner we encounter them rather than in a different fashion. The second goal is the development of computational(More)
This paper considers the control problem of an eye-in-hand type of parallel robot based precision pointing system (PRBPPS) in which the visual sensor is mounted on the platform of the parallel robot. The aim of the control is to move the platform of the parallel robot such that the image feature points reach the desired locations. An adaptive supervisory(More)
A novel pose estimation algorithm is put forward in this paper. Given the points on an object and the convex regions in which the correspondent image points lie, the concrete values of position and orientation (t and R) between the object and the camera are found based on a points to regions correspondence. The unit quaternion representation of rotation(More)
Dopamine signaling is involved in a number of brain pathways, and its disruption has been suggested to be involved in the several disease states, including Parkinson's disease (PD), schizophrenia, and attention deficit hyperactivity disorder (ADHD). It has been hypothesized that altered storage, release, and reuptake of dopamine contributes to both the(More)
Schizophrenia is a severe and complex mental disorder that causes an enormous societal and financial burden. Following the identification of dopamine as a neurotransmitter and the invention of antipsychotic drugs, the dopamine hypothesis was formulated to suggest hyperdopaminergia as the cause of schizophrenia. Over time there have been modifications and(More)