Zhen-Lin Mei

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Accumulation of amyloid-β (Aβ) is thought to be associated with the progressive neuronal death observed in Alzheimer's disease, but the mechanisms underlying neurotoxicity triggered by Aβ remain elusive. In the current study, we investigated the roles of cysteinyl leukotriene receptor 1 (CysLT1R) in Aβ1-42-induced neurotoxicity in vitro or in vivo. In vitro(More)
BACKGROUND Emerging data have demonstrated that peroxisome proliferator-activated receptor δ (PPARδ) activation confers a potentially neuroprotective role in some neurodegenerative diseases. However, whether PPARδ is involved in depression is unknown. METHODS In this study, PPARδ was firstly investigated in the chronic mild stress (CMS) and learned(More)
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