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Regulation of AChR Clustering by Dishevelled Interacting with MuSK and PAK1
It is reported here that in muscle cells, MuSK interacts with Dishevelled (Dvl), a signaling molecule important for planar cell polarity, and this interaction inhibits Agrin- and neuron-induced AChR clustering and reveals a novel function of Dvl in synapse development.
Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
It is found that intraperitoneal injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells of dorsal ventricular zone of the Fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses.
Dishevelled promotes axon differentiation by regulating atypical protein kinase C
It is found that in cultured hippocampal neurons aPKC is directly regulated by Dishevelled (Dvl), an immediate downstream effector of Wnt, and downregulation of Dvl abrogated axon differentiation, whereas Dvl overexpression resulted in multiple axon formation.
A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins.
- G. Lukinavičius, K. Umezawa, +13 authors K. Johnsson
- Chemistry, MedicineNature chemistry
- 1 February 2013
A biocompatible near-infrared silicon-rhodamine probe that can be coupled specifically to proteins using different labelling techniques, and its high permeability and fluorogenic character permit the imaging of proteins in living cells and tissues.
Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization.
A role of Lgl1, the mammalian homolog of Drosophila tumor suppressor Lethal giant larvae, in controlling membrane trafficking underlying axonal growth is reported and it is found that LGL1 is associated with plasmalemmal precursor vesicles and enriched in developing axons.
Implication of Geranylgeranyltransferase I in Synapse Formation
Evidence is provided that geranylgeranyltransferase I (GGT) is an important signaling component in the Agrin/MuSK pathway, and the notion that prenylation is necessary for AChR clustering and the NMJ formation and/or maintenance is supported.
Wnt/β-Catenin Signaling Suppresses Rapsyn Expression and Inhibits Acetylcholine Receptor Clustering at the Neuromuscular Junction*
- Jia Wang, Nan-jie Ruan, Lei Qian, Wen-liang Lei, Fei Chen, Zhen-Ge Luo
- Biology, MedicineJournal of Biological Chemistry
- 1 August 2008
The results suggest that Wnt/β-catenin signaling plays a negative role for postsynaptic differentiation at the neuromuscular junction, probably by regulating the expression of synaptic proteins, such as Rapsyn.
JIP1 Mediates Anterograde Transport of Rab10 Cargos during Neuronal Polarization
- Cai-Yun Deng, Wen-liang Lei, Xiao-hui Xu, Xiangchun Ju, Yang Liu, Zhen-Ge Luo
- Biology, MedicineThe Journal of Neuroscience
- 29 January 2014
This study has demonstrated a mechanism underlying directional membrane trafficking involved in axon development and shows that c-Jun N-terminal kinase-interacting protein 1 (JIP1) interacts with GTP-locked active form of Rab10 and directly connects Rab10 to kinesin-1 light chain (KLC).
Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury
- Miao He, Yuetong Ding, C. Chu, Jing Tang, Qi Xiao, Zhen-Ge Luo
- Biology, MedicineProceedings of the National Academy of Sciences
- 16 September 2016
A role of autophagy in regulating microtubule dynamics and axon regeneration is demonstrated and a promising effect of an autophagic-inducing reagent on injured axons is shown, providing direct evidence supporting a beneficial role of self-regulation in axons regeneration.
Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease*
- B. Liang, Bao-Yu Duan, Xiu-ping Zhou, J. Gong, Zhen-Ge Luo
- Biology, MedicineThe Journal of Biological Chemistry
- 1 July 2010
A role of calpain activation is demonstrated in the neuropathology in amyloid precursor protein (APP) and presenilin 1 (PS1) double-transgenic mice, an established mouse model of AD, and overexpression of endogenous calpain inhibitor calpastatin under the control of the calcium/calmodulin-dependent protein kinase II promoter prevented the increase of BACE1 in APP/PS1 mice.