Zhehao Zhang

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BACKGROUND As the amount of data from genome wide association studies grows dramatically, many interesting scientific questions require imputation to combine or expand datasets. However, there are two situations for which imputation has been problematic: (1) polymorphisms with low minor allele frequency (MAF), and (2) datasets where subjects are genotyped(More)
BACKGROUND Markers for individual genotyping can be selected using quantitative genotyping of pooled DNA. This strategy saves time and money. METHODS To determine the efficacy of this approach, we investigated the bivariate distribution of association test statistics from pooled and individual genotypes. We used a sample of approximately 1,000 samples(More)
Both linkage and association studies have been successfully applied to identify disease susceptibility genes with genetic markers such as microsatellites and Single Nucleotide Polymorphisms (SNPs). As one of the traditional family-based studies, the Transmission/Disequilibrium Test (TDT) measures the over-transmission of an allele in a trio from its(More)
The FingerPrint positioning method is known as a superior method in indoor positioning system that maintains previous signal strength patterns and compares with the measured new real-time signals on APs. In this paper, we analyze active signal phenomena using multi-rate Wi-Fi signals from reference AP which is accessed by multi-users. Some important factors(More)
Recent studies suggest that the traditional case-control study design does not have sufficient power to discover rare risk variants. Two different methods-collapsing and family data-are suggested as alternatives for discovering these rare variants. Compared with common variants, rare variants have unique characteristics. In this paper, we assess the(More)
Cell mechanics is a multidisciplinary field that bridges cell biology, fundamental mechanics, and micro and nanotechnology, which synergize to help us better understand the intricacies and the complex nature of cells in their native environment. With recent advances in nanotechnology, microfabrication methods and micro-electro-mechanical-systems (MEMS), we(More)
Electrochemical oxidation of 4-chloro-3-methyl phenol (CMP) was examined using Ti/SnO(2)-Sb/PbO(2) anodes. The physicochemical properties of the electrodes were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and electrochemical measurements. The degradation was studied by monitoring the total organic carbon (TOC) removal of(More)
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