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The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteome of the shell. The oyster genome is(More)
OBJECTIVE Inherited erythermalgia (erythromelalgia) is an autosomal dominant disorder in which patients experience severe burning pain in the extremities, in response to mild thermal stimuli and exercise. Although mutations in sodium channel Na(v)1.7 have been shown to underlie erythermalgia in several multigeneration families with the disease that have(More)
Ca(2+) oscillations and signaling represent a basic mechanism for controlling many cellular events. Activation of mouse eggs entrains a temporal series of Ca(2+)-dependent events that include cortical granule exocytosis, cell cycle resumption with concomitant decreases in MPF and MAP kinase activities, and recruitment of maternal mRNAs. The outcome is a(More)
We present a novel interface for human-robot interaction that enables a human to intuitively and unambiguously select a 3D location in the world and communicate it to a mobile robot. The human points at a location of interest and illuminates it (``clicks it'') with an unaltered, off-the-shelf, green laser pointer. The robot detects the resulting laser spot(More)
Architectural style classification differs from standard classification tasks due to the rich inter-class relationships between different styles, such as re-interpretation, revival, and territoriality. In this paper, we adopt Deformable Part-based Models (DPM) to capture the morphological characteristics of basic architectural components and propose(More)
The homeodomain (HD) protein Bicoid (Bcd) is thought to function as a gradient morphogen that positions boundaries of target genes via threshold-dependent activation mechanisms. Here, we analyze 66 Bcd-dependent regulatory elements and show that their boundaries are positioned primarily by repressive gradients that antagonize Bcd-mediated activation. A(More)
In an effort to understand the olfactory code of rats, we collected more than 1,500,000 measurements of glomerular activity in response to 54 odorants selected to provide differences in functional groups and hydrocarbon structure. Each odorant evoked a unique response pattern by differentially stimulating clusters of glomeruli, called modules. Odorants(More)
In order to further understand what physiological characteristics make a human hand irreplaceable for many dexterous tasks, it is necessary to develop artificial joints that are anatomically correct while sharing similar dynamic features. In this paper, we address the problem of designing a two degree of freedom metacarpophalangeal (MCP) joint of an index(More)
In the context of fine-grained visual categorization, the ability to interpret models as human-understandable visual manuals is sometimes as important as achieving high classification accuracy. In this paper, we propose a novel Part-Stacked CNN architecture that explicitly explains the finegrained recognition process by modeling subtle differences from(More)
We propose a new method for fine-grained object recognition that employs part-level annotations and deep convolutional neural networks (CNNs) in a unified framework. Although both schemes have been widely used to boost recognition performance, due to the difficulty in acquiring detailed part annotations, strongly supervised fine-grained datasets are usually(More)