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PURPOSE Mutations in the ABCA4 gene are heterogeneous and somewhat ethnic specific and can result in autosomal recessive Stargardt disease (STGD1), cone or cone-rod dystrophy (CRD), and retinitis pigmentosa. The objective of this study was to determine the ABCA4 mutation detection rate and mutation spectrum in a cohort of Chinese patients with STGD1 or CRD(More)
OBJECTIVE To identify the causative mutations in two Chinese families with retinitis pigmentosa (RP), and to describe the associated phenotype. METHODS Individuals from two unrelated families underwent full ophthalmic examinations. After informed consent was obtained, genomic DNA was extracted from the venous blood of all participants. Linkage analysis(More)
PURPOSE X-linked retinoschisis is a retinal dystrophy caused by mutations in the RS1 gene in Xp22.1. These mutations lead to schisis (splitting) of the neural retina and subsequent reduction in visual acuity in affected men (OMIM # 312700). The aim of this study was to identify the RS1 gene mutations in a cohort of Chinese patients with X-linked(More)
PURPOSE To examine the relationships between axial length and foveal and peripheral retinal thickness. METHODS Using optical coherence tomography, foveal retinal thickness was measured in participants of the population-based Beijing Eye Study without optic nerve or macula diseases. Inner and outer nuclear layer thickness as surrogate for retinal thickness(More)
PURPOSE To measure retinal nerve fiber layer (RNFL) thickness in a population-based setting. METHODS In the population-based Beijing Eye Study 2011 with 3468 individuals, RNFL thickness was measured in a subgroup of 1654 (47.7%) study participants by spectral domain optical coherence tomography (iVue SD-OCT). RESULTS Mean RNFL thickness was(More)
PURPOSE To describe the clinical and genetic findings in two Chinese families with retinitis pigmentosa (RP). METHODS Two unrelated families were examined clinically. After informed consent was obtained, genomic DNA was extracted from the venous blood of all participants. Genotyping and haplotyping analysis was performed on the known genetic loci for(More)
Nanostructures: A new air-stable π-extended condensed benzothiophene was prepared by starting from 4,8-dioctyl-oxybenzo[1,2-b:4,5-b']dithiophene in about 54 % overall yield. Highly ordered 1D organic nanoribbons of the resultant compound were formed by molecular self-assembly. An individual nanoribbon-based organic field-effect transistor (see figure)(More)
PURPOSE To demonstrate the feasibility, safety, and technical strategies of hand-assisted laparoscopic complete mesocolic excision (HAL-CME) and to compare oncological outcomes between HAL-CME and the open approach (O-CME) for right colon cancers. METHODS Patients who were scheduled to undergo a right hemicolectomy were divided into HAL-CME and O-CME(More)
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