Learn More
A key technical barrier to furthering our understanding of complex neural networks has been the lack of tools for the simultaneous spatiotemporal control and detection of activity in a large number of neurons. Here, we report an all-optical system for achieving this kind of parallel and selective control and detection. We do this by delivering(More)
Hyperlenses have generated much interest recently, not only because of their intriguing physics but also for their ability to achieve sub-diffraction imaging in the far field in real time. All previous efforts have been limited to sub-wavelength confinement in one dimension only and at ultraviolet frequencies, hindering the use of hyperlenses in practical(More)
BACKGROUND Analysis of an allelic series of point mutations in a gene, generated by N-ethyl-N-nitrosourea (ENU) mutagenesis, is a valuable method for discovering the full scope of its biological function. Here we present an efficient gene-driven approach for identifying ENU-induced point mutations in any gene in C57BL/6J mice. The advantage of such an(More)
The diffraction limit of light, which is causd by the loss of evanescent waves in the far field that carry high spatial frequency information, limits the resolution of optical lenses to the order of the wavelength of light. We report experimental demonstration of the optical hyperlens for sub-diffraction-limited imaging in the far field. The device(More)
Negative refraction in metamaterials has generated great excitement in the scientific community. Although negative refraction has been realized in microwave and infrared by using metamaterials and by using two-dimensional waveguide structures, creation of a bulk metamaterial showing negative refraction at visible frequency has not been successful, mainly(More)
Nano-sized materials are now being used in medicine, biotechnology, energy, and environmental technology. Although a wide and growing number of applications for nanomaterials exist, there are limited studies available on toxicity of nanoparticles for their human risk and environmental assessment. The aim of this study was to investigate the effects of(More)
PURPOSE Compressed sensing theory has enabled an accurate, low-dose cone-beam computed tomography (CBCT) reconstruction using a minimal number of noisy projections. However, the reconstruction time remains a significant challenge for practical implementation in the clinic. In this work, we propose a novel gradient projection algorithm, based on the(More)
We report the focusing of surface plasmon polaritons by circular and elliptical structures milled into optically thick metallic films or plasmonic lenses. Both theoretical and experimental data for the electromagnetic nearfield is presented. The nearfield is mapped experimentally using nearfield scanning optical microscopy and plasmonic lithography. We find(More)
Far-field optical lens resolution is fundamentally limited by diffraction, which typically is about half of the wavelength. This is due to the evanescent waves carrying small scale information from an object that fades away in the far field. A recently proposed superlens theory offers a new approach by surface excitation at the negative index medium. We(More)
The resolution of conventional optical lens systems is always hampered by the diffraction limit. Recent developments in artificial metamaterials provide new avenues to build hyperlenses and metalenses that are able to image beyond the diffraction limit. Hyperlenses project super-resolution information to the far field through a magnification mechanism,(More)