Macrophage ABCG1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice
- Ruud Out, M. Hoekstra, M. Van Eck
- Biology, MedicineArteriosclerosis, Thrombosis and Vascular Biology
- 1 October 2006
Macrophage ABCG1 deficiency does lead to heavy lipid accumulation in macrophages of the lung, and also a moderately significant effect on atherosclerotic lesion development was observed.
Activation of the nuclear receptor PXR decreases plasma LDL-cholesterol levels and induces hepatic steatosis in LDL receptor knockout mice.
- M. Hoekstra, B. Lammers, Ruud Out, Zhaosha Li, M. Van Eck, T. V. van Berkel
- Biology, ChemistryMolecular Pharmaceutics
- 2009
It is shown that activation of the nuclear receptor PXR by PCN leads to an inhibition of the plasma HL-mediated lipolysis rate, which is associated with a decrease in plasma LDL-cholesterol levels and induction of hepatic steatosis in LDL receptor knockout mice.
The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status.
- M. Hoekstra, Zhaosha Li, J. K. Kruijt, M. Van Eck, T. V. van Berkel, J. Kuiper
- Biology, MedicineJournal of Hepatology
- 1 February 2010
Repression of miR-217 protects against high glucose-induced podocyte injury and insulin resistance by restoring PTEN-mediated autophagy pathway.
- Juan Sun, Zhaosha Li, Rui Zhang, Hui Zhang
- Biology, MedicineBiochemical and Biophysical Research…
- 29 January 2017
Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice.
- M. Hoekstra, S. Korporaal, Zhaosha Li, Ying-Yue Zhao, M. Van Eck, T. V. van Berkel
- Biology, MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 December 2010
Lipoprotein deficiency in mice as a result of probucol feeding is associated with decreased adrenal cortex cholesterol levels, a lower basal and stress-induced plasma glucocorticoid level, and an increased susceptibility to LPS-induced inflammation.
Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice.
- Zhaosha Li, Yanan Wang, M. Hoekstra
- Biology, MedicineBiochemical Pharmacology
- 15 September 2012
Macrophage ABCG 1 Deletion Disrupts Lipid Homeostasis in Alveolar Macrophages and Moderately Influences Atherosclerotic Lesion Development in LDL Receptor-Deficient Mice
- Ruud Out, M. Hoekstra, M. Eck
- Biology, Medicine
- 2006
Macrophage ABCG1 deficiency does lead to heavy lipid accumulation in macrophages of the lung, and also a moderately significant effect on atherosclerotic lesion development was observed.
Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development.
- Marco van der Stoep, Zhaosha Li, M. Hoekstra
- Biology, MedicineBiochemical Pharmacology
- 1 December 2013
Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells.
- Zhaosha Li, J. K. Kruijt, R. J. van der Sluis, T. V. van Berkel, M. Hoekstra
- Biology, MedicinePhysiological Genomics
- 1 April 2013
The gene expression catalog suggests that orphan nuclear receptors such as COUP-TFII, EAR2, and TR4 may be of significant importance as novel targets for pharmaceutical interventions in liver.
FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice
- M. Hoekstra, R. V. Sluis, Zhaosha Li, M. Oosterveer, A. Groen, T. J. Berkel
- Biology, MedicineMolecular and Cellular Endocrinology
- 15 October 2012
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