Zhaoqing Guo

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To clarify the mechanism of the stimulatory effect of statins on bone formation, we investigated the effect of simvastatin, a widely used statin, on osteoblastic and adipocytic differentiation in primary cultured mouse bone marrow stromal cells (BMSCs). Simvastatin treatment enhanced the expression level of mRNA for osteocalcin and protein for osteocalcin(More)
STUDY DESIGN A case-control association study was conducted to investigate the genetic etiology for ossification of the ligamentum flavum (OLF) and ossification of the posterior longitudinal ligament of the spine (OPLL). OBJECTIVE To determine whether COL6A1 polymorphisms are associated with susceptibility to OLF and OPLL in Chinese Han population. (More)
Mechanical stress is considered to be an important factor in the progression of thoracic ossification of the ligament flavum (TOLF). To elucidate the mechanism underlying mechanical stress-induced TOLF, we investigated the effect of stretching on cultured flavum ligament cells derived from TOLF and non-TOLF patients. We found that the mRNA expression of(More)
STUDY DESIGN A clinical retrospective study. OBJECTIVE To analyze the complications and relevant management of the correction procedure for focal kyphosis. SUMMARY OF BACKGROUND DATA The treatment of focal kyphosis is a difficult problem in spine surgery. The potential complications of surgery should be considered cautiously and managed positively. (More)
STUDY DESIGN Retrospective and radiological analysis of spinopelvic sagittal alignment in Chinese patients with thoracic and thoracolumbar kyphosis. OBJECTIVE To determine the impact of thoracic and thoracolumbar kyphosis on pelvic sagittal morphology and the mechanisms of adjusting trunk sagittal balance. SUMMARY OF BACKGROUND DATA Previous studies(More)
OBJECTIVES To analyze the clinical characteristics and surgical results of posttraumatic kyphosis of the thoracolumbar segment. METHODS Thirty-four patients with posttraumatic kyphosis of the thoracolumbar segment underwent posterior osteotomy, kyphosis correction, and fixation at our hospital. The kyphosis apex was from T10 to L2. There were 15 male and(More)
OBJECTIVE To study the risk factors for deep surgical site infection after posterior thoracic and lumbar surgery. METHODS The medical data of the patients with deep surgical site infection after posterior thoracic and lumbar surgery from January 2008 to December 2013 were reviewed.For each case patient, 3 non-infected controls were randomly selected from(More)
BACKGROUND Lumbar disk herniation in adults is thought to be caused by repetitive overloading and age-rated degenerative changes. However, these causes are absent in children and adolescent patients. We assume that structural malformations in the lumbar spine could predispose intervertebral disks to early degeneration and hence need to be surgically fused.(More)
OBJECT The object of this study was to compare the clinical and radiographic outcomes of 36 patients with posttuberculosis kyphosis who underwent one of two types of osteotomy. METHODS Each patient underwent single-stage correction via a posterior surgical approach. A modified pedicle subtraction osteotomy (mPSO) was performed when the kyphotic deformity(More)
OBJECTIVE To observe the effects of the intermittent hydromechanical stimulation on the differentiation and function of the bone marrow stromal derived-osteoblasts in the porous calcium phosphate ceramics. METHODS Rat bone marrow stromal derived-osteoblasts were seeded into porous calcium phosphate ceramic scaffolds at cells density 1 x 10(6) cells/cm(3).(More)