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To clarify the mechanism of the stimulatory effect of statins on bone formation, we investigated the effect of simvastatin, a widely used statin, on osteoblastic and adipocytic differentiation in primary cultured mouse bone marrow stromal cells (BMSCs). Simvastatin treatment enhanced the expression level of mRNA for osteocalcin and protein for osteocalcin(More)
STUDY DESIGN A case-control association study was conducted to investigate the genetic etiology for ossification of the ligamentum flavum (OLF) and ossification of the posterior longitudinal ligament of the spine (OPLL). OBJECTIVE To determine whether COL6A1 polymorphisms are associated with susceptibility to OLF and OPLL in Chinese Han population. (More)
STUDY DESIGN A clinical retrospective study. OBJECTIVE To analyze the complications and relevant management of the correction procedure for focal kyphosis. SUMMARY OF BACKGROUND DATA The treatment of focal kyphosis is a difficult problem in spine surgery. The potential complications of surgery should be considered cautiously and managed positively. (More)
STUDY DESIGN Retrospective and radiological analysis of spinopelvic sagittal alignment in Chinese patients with thoracic and thoracolumbar kyphosis. OBJECTIVE To determine the impact of thoracic and thoracolumbar kyphosis on pelvic sagittal morphology and the mechanisms of adjusting trunk sagittal balance. SUMMARY OF BACKGROUND DATA Previous studies(More)
OBJECTIVE To study the risk factors for deep surgical site infection after posterior thoracic and lumbar surgery. METHODS The medical data of the patients with deep surgical site infection after posterior thoracic and lumbar surgery from January 2008 to December 2013 were reviewed.For each case patient, 3 non-infected controls were randomly selected from(More)
PURPOSE The purpose of this study is to review our operative experience of congenital kyphosis or kyphoscoliosis undergoing either pedicle subtraction osteotomy (PSO) or posterior vertebral column resection (pVCR) according to certain criteria we have established. METHODS From December 2003 to 2009, 23 consecutive patients of congenital kyphosis or(More)
Mechanical stress is considered to be an important factor in the progression of thoracic ossification of the ligament flavum (TOLF). To elucidate the mechanism underlying mechanical stress-induced TOLF, we investigated the effect of stretching on cultured flavum ligament cells derived from TOLF and non-TOLF patients. We found that the mRNA expression of(More)
BACKGROUND Lumbar disk herniation in adults is thought to be caused by repetitive overloading and age-rated degenerative changes. However, these causes are absent in children and adolescent patients. We assume that structural malformations in the lumbar spine could predispose intervertebral disks to early degeneration and hence need to be surgically fused.(More)
STUDY DESIGN Retrospective review. OBJECTIVE To perform a single-institution analysis of incidence, treatment, and clinical outcome in patients with thoracic ossification of the ligamentum flavum (OLF) who experienced dural tears and cerebrospinal fluid (CSF) leakage. SUMMARY OF BACKGROUND DATA There is a paucity of clinical reports focusing on dural(More)
STUDY DESIGN The study was undertaken to compare the expression and activity of tissue transglutaminase (TG2) in human ligamentum flavum cells derived from ossification of the ligamentum flavum (OLF) and non-OLF patients. OBJECTIVE To determine whether TG2 is involved in the pathologic process of OLF. SUMMARY OF BACKGROUND DATA OLF is a disease(More)