Zhaolan Gao

  • Citations Per Year
Learn More
Alzheimer’s disease is characterized by the abnormal aggregation of amyloid-β peptide (Aβ) in extracellular deposits known as senile plaques. However, the nature of the toxic Aβ species and its precise mechanism of action remain unclear. Previous reports suggest that the histidine residues are involved in copper–Aβ interaction, by which resulting in the(More)
Alzheimer's disease (AD) is characterized by a large number of amyloid-β (Aβ) deposits in the brain. Therefore, inhibiting Aβ aggregation or destabilizing preformed aggregates could be a promising therapeutic target for halting/slowing the progression of AD. Chitosan oligosaccharides (COS) have previously been reported to exhibit antioxidant and(More)
Amyloid precursor protein (APP) proteolysis is essential for the production of β-amyloid peptides (Aβ) that form senile plaques in Alzheimer's disease (AD) brains. The β-site amyloid protein precursor cleaving enzyme 1 (BACE1) is the rate limiting enzyme in the generation of Aβ from APP, inhibition of BACE1 is thereby considered as an attractive strategy(More)
AIM The objective of the present study was two-fold: (i) to evaluate the modulating effects of chitosan oligosaccharides (COS) on cognitive deficits and (ii) to explore their underlying molecular mechanisms. METHODS The Morris water maze and passive avoidance tests were used to determine the neuroprotective effects of COS on Aβ1-42-induced learning and(More)
  • 1