Zhaojun Wang

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IFN-gamma is an important Th1 proinflammatory cytokine and has a paradoxical effect on EAE in which disease susceptibility is unexpectedly heightened in IFN-gamma-deficient mice. In this study, we provide what we believe is new evidence indicating that IFN-gamma is critically required for the conversion of CD4+ CD25- T cells to CD4+ Tregs during EAE. In our(More)
Mesenchymal stem cells (MSCs)-based regenerative therapy is currently regarded as an alternative approach to salvage the acute myocardial infarcted hearts. However, the efficiency of MSCs transplantation is limited by lower survival rate of engrafted MSCs. In previous study, we found that 1.0 μg/ml Lipopolysaccharide (LPS) could protect MSCs against(More)
One essential issue of document clustering is to estimate the appropriate number of clusters for a document collection to which documents should be partitioned. In this paper, we propose a novel approach, namely DPMFS, to address this issue. The proposed approach is designed 1) to group documents into a set of clusters while the number of document clusters(More)
Finding the appropriate number of clusters to which documents should be partitioned is crucial in document clustering. In this paper, we propose a novel approach, namely DPMFP, to discover the latent cluster structure based on the DPM model without requiring the number of clusters as input. Document features are automatically partitioned into two groups, in(More)
Ethyl 2-[4-(12-beta-artemisininoxy)]phenoxylpropionate (SM933) is a novel derivative of artemisinin, an herbal compound approved for the treatment of malaria. In this study, we show that SM933 has unique anti-inflammatory properties through regulation of signaling pathways, leading to amelioration of experimental autoimmune encephalomyelitis. The(More)
Phagocytosis and oxidative burst are two major effector arms of innate immunity. Although it is known that both are activated by Toll-like receptors (TLRs) and Rac GTPases, how their strengths are controlled in quiescent and TLR-activated cells is not clear. We report here that TIPE2 (TNFAIP8L2) serves as a negative regulator of innate immunity by linking(More)
Recently, monitoring the process mean and variance simultaneously by using a single chart has drawn more and more attention. In this paper, we propose a new single chart that integrates the EWMA procedure with the generalized likelihood ratio (GLR) test statistics for jointly monitoring both the process mean and variance. It can be easily designed and(More)
Alzheimer's disease (AD) is the most common cause of dementia, and effective therapeutics are lacking. Colivelin (CLN), a novel, strong humanin derivative, is effective in vitro in preventing cell death induced by AD-causative genes and amyloid-β protein (Aβ) even at a low concentration. We recently demonstrated that intrahippocampal injection of CLN(More)