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BACKGROUND Higher-order aberrations and contrast sensitivity were evaluated in patients who underwent phacoemulsification cataract extraction followed by implantation of aspherical, monofocal or multifocal intraocular lens (IOL) replacements. METHODS In this comparative trial, 124 patients with an average age of 66.8+/-5.2 years and their 124 eyes were(More)
BACKGROUND A wide range of organisms that enter the eye following ocular trauma can cause endophthalmitis. This study was to investigate the spectrum of pathogens and antibiotic susceptibility of bacterial isolates from a large cohort of post-traumatic endophthalmitis cases. METHODS A retrospective study of 912 post-traumatic endophthalmitis patients(More)
PURPOSE To compare the intraoperative and short-term postoperative outcomes of cataract surgery performed with torsional mode and conventional ultrasound mode using the Infiniti Vision System (Alcon Laboratories). SETTING Cataract Service, Zhongshan Ophthalmic Center, Sun-Yat-Sen University, Guangzhou, China. METHODS In this randomized comparative(More)
PURPOSE We have manufactured a novel human foldable capsular vitreous body (FCVB). In this article, we determine whether the human FCVB releases levofloxacin in vitro and evaluate the release characteristics. METHODS Levofloxacin at dosages of 100, 250, and 500 μg/mL in 4.0 mL H2O was injected into the novel human FCVB; then, the capsules were immersed in(More)
The first human infection with avian influenza A(H7N9) virus was reported in Shanghai, China in March 2013. An additional 32 cases of human H7N9 infection were identified in the following months from March to April 2013 in Shanghai. Here we conducted a case-control study of the patients with H7N9 infection (n = 25) using controls matched by age, sex, and(More)
BACKGROUND Suture exposure remains to be a potential problem of transscleral fixated posterior chamber intraocular lens (PCIOL). We report a modified technique to minimize the risk of suture exposure for the transscleral fixation of PCIOL. METHODS The modified surgical technique is as following: at first, two 3 mm × 4 mm square scleral pockets were(More)
OBJECTIVE To determine whether that free fatty acids (FFAs) impair glucose metabolism is associated with altered insulin signaling system. METHODS After skeletal muscle and hepatic cells were incubated with palmitate (0.25 mmol/L) or oleate (0.125 mmol/L) for 6, 12 or 24 hours, the protein abundance of SH-PTP2 and PTP1B was assessed by western blot. (More)
PURPOSE To study the clinical characteristics, therapeutic efficacy and investigate prognostic factors of endogenous endophthalmitis. METHODS Twenty-eight cases (28 eyes) of endogenous endophthalmitis were surveyed retrospectively. The clinical characteristics, primary infection foci, predisposing systemic disease, complications, pathogens examination,(More)
PURPOSE To compare the chymotrypsin-like and trypsin-like activity of proteasome in the epithelium of human age-related cataract and normal lens, in order to study the mechanism of the proteasome in the formation and development of age-related cataract. METHODS Cataractous lens were obtained during cataract surgery of Zhongshan Ophthalmic Center, and(More)
PURPOSE To elucidate the role of adhesion molecules in the pathogenesis of herpes simplex keratitis. METHODS Fifty female Balb/c mice (4~6 weeks old, 14~22 g weight) were divided into two groups randomly. Forty were infected by herpes simplex virus and the other 10 were used as normal controls. All mice were fed under the same conditions. Corneas of these(More)