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Biodegradable synthetic polymers: Preparation, functionalization and biomedical application
Abstract Biodegradable polymers have been widely used and have greatly promoted the development of biomedical fields because of their biocompatibility and biodegradability. The development ofExpand
Well-defined polymer-drug conjugate engineered with redox and pH-sensitive release mechanism for efficient delivery of paclitaxel.
A novel anti-cancer PDC engineered with side groups of disulfide and ester bonds for on-demand delivery of paclitaxel (PTX) with redox and pH dual sensitive behaviors provides a useful strategy for anti-tumor drug delivery. Expand
Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer.
In vitro cytotoxicity assays against A549 human lung adenocarcinoma cell line demonstrated that the DOX + PTX co-delivered nanoparticles (Co-NPs) exhibited synergistic effect in inducing cancer cell apoptosis, indicating this co- delivery system with different functional antitumor drugs provides the clinical potential in cancer therapy. Expand
Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy.
In vivo studies on the subcutaneous non-small cell lung cancer (A549) xenograft nude mice model confirmed that DOX-NP showed significant antitumor activity and reduced side effects, and then enhanced tumor accumulation as a result of the prolonged circulation in blood and the enhanced permeation and retention effect, indicating its great potential for cancer therapy. Expand
Stimuli-sensitive synthetic polypeptide-based materials for drug and gene delivery.
This Review focuses on recent advances in stimuli-sensitive polypeptide-based materials that have been designed and evaluated for drug and gene delivery applications and recent developments in the preparation of stimuli- sensitive functionalizedpolypeptides. Expand
Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin.
These cisplatin prodrug crosslinked polysaccharide nanoparticles proved to be a promising nanomedicine drug delivery system for tumor-targeted delivery of DOX and exhibited enhanced therapeutic efficacy in tumor-bearing mice. Expand
Facile Synthesis of Glycopolypeptides by Combination of Ring-Opening Polymerization of an Alkyne-Substituted N-carboxyanhydride and Click "Glycosylation".
This work presents a facile route to preparation of glycopolypeptides with highly effective "glycosylation" by click postpolymerization modification by synthesizing and polymerizing a N-carboxyanhydride monomer. Expand
Polypeptide-based combination of paclitaxel and cisplatin for enhanced chemotherapy efficacy and reduced side-effects.
The polypeptide-based combination of PTX and CDDP may provide useful guidance for effective and safe cancer chemotherapy. Expand
Preparation of photo-cross-linked pH-responsive polypeptide nanogels as potential carriers for controlled drug delivery
Diblock and triblock copolymers, including poly(ethylene glycol monomethyl ether)-b-poly(L-glutamic acid-co-γ-cinnamyl-L-glutamate) (mPEG-b-P(LGA/CLG)) and poly(L-glutamicExpand
Linear and four‐armed poly(l‐lactide)‐block‐poly(d‐lactide) copolymers and their stereocomplexation with poly(lactide)s
Linear and four-armed poly(l-lactide)-block-poly(d-lactide) (plla-b-pdla) block copolymers are synthesized by ring-opening polymerization of d-lactide on the end hydroxyl of linear and four-armedExpand