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Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9
TLDR
It is shown that leukaemia stem cells (LSC) can maintain the global identity of the progenitor from which they arose while activating a limited stem-cell- or self-renewal-associated programme. Expand
The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML
TLDR
It is shown that the Wnt/β-catenin signaling pathway is required for self-renewal of LSCs that are derived from either hematopoietic stem cells (HSC) or more differentiated granulocyte-macrophage progenitors (GMP). Expand
The coordinate regulation of the p53 and mTOR pathways in cells.
TLDR
The results presented here demonstrate that activation of p53 inhibits mTOR activity and regulates its downstream targets, including autophagy, a tumor suppression process, and that p53 and mTOR signaling machineries can cross-talk and coordinately regulate cell growth, proliferation, and death. Expand
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
TLDR
This study explores four p53-regulated gene products, the beta1 and beta2 subunits of the AMPK, which are shown for the first time to be regulated by the p53 protein, TSC2, PTEN, and IGF-BP3, each of which negatively regulates the IGF-1-AKT-mTOR pathways after stress. Expand
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
TLDR
Inactivation of Dot1l led to downregulation of direct MLL-AF9 targets and an MLL translocation-associated gene expression signature, whereas global gene expression remained largely unaffected. Expand
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
TLDR
It is demonstrated that ectopic H3K79 methylation is a distinguishing feature of murine and human MLL-AF4 ALLs and is important for maintenance of MLL -AF4-driven gene expression. Expand
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
TLDR
Results indicated that changes in the rate of lipid oxidation in selective hypothalamic neurons signaled nutrient availability to the hypothalamus, which in turn modulated the exogenous and endogenous inputs of nutrients into the circulation. Expand
Central administration of oleic acid inhibits glucose production and food intake.
TLDR
It is reported that intracerebroventricular administration of the long-chain fatty acid oleic acid markedly inhibits glucose production and food intake and limits further delivery of nutrients to the circulation. Expand
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
TLDR
Results demonstrated that as a unique p53 target gene, GLS2 is a mediator of p53’s role in energy metabolism and antioxidant defense, which can contribute to its role in tumor suppression. Expand
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
TLDR
Insulin receptors in discrete areas of the hypothalamus have a physiological role in the control of food intake, fat mass and hepatic action of insulin. Expand
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