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Toxicity assessments with Daphnia magna of Guadipyr, a new neonicotinoid insecticide and studies of its effect on acetylcholinesterase (AChE), glutathione S-transferase (GST), catalase (CAT) and…
The Fungicidal Terpenoids and Essential Oil from Litsea cubeba in Tibet
The preliminary bioassay results showed that 1 and 2 have good fungicidal activities against Sclerotinia sclerotiorum, Thanatephorus cucumeris, Pseudocer-cospora musae and Colletotrichum gloeosporioides, and the essential oil has good fungicide activities against T. cucumerIS and S. sclerOTiorum.
Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici.
Morphological and ultrastructural studies showed that p Skyrimorph caused excessive septation and swelling of hyphae, distortion and disruption of most vacuoles, thickening and development a multilayer cell wall, and accumulation of dense bodies, which suggested pyrimorph exhibited multiple modes of action including impairment of the energy generation system and effect on cell wall biosynthesis directly or indirectly.
Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III*
It is shown that the binding of oxazolidinedione-type inhibitors famoxadone, jg144, and fenamidone induces docking of the ISP to the QP site in the absence of the H-bond formation both in mitochondrial and bacterial cyt bc1 complexes, demonstrating that ISP docking is independent of the proposed direct ISP-inhibitor interaction.
Effect of pyrimorph on soil enzymatic activities and respiration
TPP-based mitocans: a potent strategy for anticancer drug design.
- Jiayao Wang, Jiaqi Li, Yumei Xiao, B. Fu, Zhaohai Qin
- Biology, ChemistryRSC medicinal chemistry
- 1 August 2020
This review systematically summarize various mitochondrial anticancer drugs developed, especially mitocans based on triphenylphosphonium (TPP), and discusses the advantages of TPP in endowing mitochondrial targeting function.
Acute toxicity and bioconcentration of pyrimorph in zebrafish, Brachydanio rerio.
- C. Zhao, Boqian Liu, Jing Wang, Nan Li, Zhaohai Qin, Lihong Qiu
- BiologyPest management science
- 1 September 2011
The novel fungicide pyrimorph has low toxicity to zebrafish; however, it showed medium BCF to z stripes; therefore, more attention should be paid to the residue of p Skyrimorph in fish, as well as to its long-term ecological effects.
A new coumarin–rhodamine FRET system as an efficient ratiometric fluorescent probe for Hg2+ in aqueous solution and in living cells
Resistance to the Novel Fungicide Pyrimorph in Phytophthora capsici: Risk Assessment and Detection of Point Mutations in CesA3 That Confer Resistance
Comparison of CesA3 in isolates with a high level of pyrimorph resistance and parental isolates showed that an amino acid change from glutamine to lysine at position 1077 resulted in stable, high resistance in the mutants, indicating that point mutations in cellulose synthase 3 (CesA3) may confer resistance to p Skyrimorph.
Studies on Inhibition of Respiratory Cytochrome bc 1 Complex by the Fungicide Pyrimorph Suggest a Novel Inhibitory Mechanism
It is shown that pyrimorph blocks mitochondrial electron transport by affecting the function of cyt bc 1, and falls into the category of a mixed-type, noncompetitive inhibitor with respect to the substrate ubiquinol.