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OBJECTIVES The present study was designed to investigate the role of a mitochondrial enzyme pyruvate dehydrogenase (PDH) on the severity of brain injury, and the effects of pyruvate treatment in rats with traumatic brain injury (TBI). METHODS We examined rats subjected to closed head injury using a fluid percussion device, and treated with sodium pyruvate(More)
Dysregulated expression of microRNAs (miRNA) is a hallmark of cancer. miR-16 has been reported to be downregulated and to act as a tumor suppressor in different cancer types. In the present study, we sought to investigate the possible roles and mechanisms of miR-16 and its relationship with p53 and survivin in CRC cells.(More)
Dear Editor: Most children who have had a definitive pull-through operation for Hirschsprung’s disease (HD) have excellent results. In a minority of patients, constipation, encopresis, enterocolitis, and motility disturbances are found on longterm follow-up. Although the reasons for these persistent symptoms are not always clear, the cause in some of the(More)
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