Zhao Zeng

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Transient receptor potential melastatin 7 (TRPM7), a non-selective cation channel, is highly expressed expressed in the brain and plays a critical role in ischemic neuronal death. Astrocyte, the most abundant cell type in central nervous system (CNS), exerts many essential functions in the physiological and pathological conditions. Here we investigated the(More)
BACKGROUND Previous study demonstrated that overstimulation of TRPM7 substantially contributes to zinc-mediated neuronal toxicity. Inhibition of TRPM7 activity and TRPM7-mediated intracellular Zn(2+) accumulation may represent a promising strategy in the treatment of stroke. AIMS To investigate whether local anesthetics lidocaine could inhibit TRPM7(More)
This study investigated the change of transient receptor potential melastatin 7 (TRPM7) expression by high glucose and its role in hyperglycemia induced injury of vascular endothelial cells. Human umbilical vein endothelial cells (HUVECs) were incubated in the presence or absence of high concentrations of D-glucose (HG) for 72 h. RT-PCR, Real-time PCR,(More)
Cross-lingual sentiment classification aims to automatically predict sentiment polarity (e.g., positive or negative) of data in a label-scarce target language by exploiting labeled data from a label-rich language. The fundamental challenge of cross-lingual learning stems from a lack of overlap between the feature spaces of source language data and that of(More)
  • Zhao Zeng, David J. J. de Gorter, Maria Kowalski, Peter ten Dijke, Osamu Shimmi
  • 2014
Bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor (TGF)-β family, transduce their signal through multiple components downstream of their receptors. Even though the components involved in the BMP signaling pathway have been intensely studied, many molecules mediating BMP signaling remain to be addressed. To identify novel(More)
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