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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.
Reactive oxygen species (ROS) stimulate cell proliferation and induce genetic instability, and their increase in cancer cells is often viewed as an adverse event. Here, we show that such abnormal… Expand
Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial.
CONTEXT In the Women's Health Initiative trial of estrogen-plus-progestin therapy, women assigned to active treatment had fewer fractures. OBJECTIVE To test the hypothesis that the relative risk… Expand
Ethnicity and breast cancer: factors influencing differences in incidence and outcome.
- R. Chlebowski, Zhao Chen, +9 authors R. Prentice
- Journal of the National Cancer Institute
- 2 November 2005
BACKGROUND The lower breast cancer incidence in minority women and the higher breast cancer mortality in African American women than in white women are largely unexplained. The influence of breast… Expand
Does Obesity Really Make the Femur Stronger? BMD, Geometry, and Fracture Incidence in the Women's Health Initiative‐Observational Study
- T. Beck, M. Petit, G. Wu, M. Leboff, J. Cauley, Zhao Chen
- Medicine, Biology
- Journal of bone and mineral research : the…
- 1 August 2009
Heavier individuals have higher hip BMD and more robust femur geometry, but it is unclear whether values vary in proportion with body weight in obesity. We studied the variation of hip BMD and… Expand
Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.
Lung squamous cell carcinoma (SCC) is a deadly disease for which current treatments are inadequate. We demonstrate that biallelic inactivation of Lkb1 and Pten in the mouse lung leads to SCC that… Expand
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
Both PU.1 (also called SFPI1), an Ets-family transcription factor, and AML1 (also called RUNX1), a DNA-binding subunit of the CBF transcription factor family, are crucial for the generation of all… Expand
Dynamic Visualization of Thrombopoiesis Within Bone Marrow
Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here we describe the use of multiphoton intravital microscopy in intact BM… Expand
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
- A. Faber, D. Li, +9 authors J. Engelman
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 17 November 2009
Non-small cell lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are highly responsive to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib.… Expand
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
- H. Ebi, R. Corcoran, +10 authors J. Engelman
- Biology, Medicine
- The Journal of clinical investigation
- 1 November 2011
Therapies inhibiting receptor tyrosine kinases (RTKs) are effective against some human cancers when they lead to simultaneous downregulation of PI3K/AKT and MEK/ERK signaling. However, mutant KRAS… Expand
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism.
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia, and resistance to fludarabine-based therapies is a major challenge in CLL treatment. Because CLL cells are known to have elevated… Expand