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Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial.
It is demonstrated that estrogen plus progestin increases BMD and reduces the risk of fracture in healthy postmenopausal women and there was no net benefit when considering the effects of hormone therapy on other important disease outcomes in a global model.
Ethnicity and breast cancer: factors influencing differences in incidence and outcome.
Differences in breast cancer incidence rates between most racial/ethnic groups were largely explained by risk factor distribution except in African Americans, however, breast cancers in African American women more commonly had characteristics of poor prognosis, which may contribute to their increased mortality after diagnosis.
Does Obesity Really Make the Femur Stronger? BMD, Geometry, and Fracture Incidence in the Women's Health Initiative‐Observational Study
Femur BMD, CSA, and SM were larger in women with higher BMI, but values scaled in proportion to lean and not to fat or total body mass, supporting the view that bones adapt to prevalent muscle loads.
Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.
A magnesium consumption slightly greater than the Recommended Dietary Allowance is associated with increased lower-arm and wrist fractures that are possibly related to more physical activity and falls.
Fat or Lean Tissue Mass: Which One Is the Major Determinant of Bone Mineral Mass in Healthy Postmenopausal Women?
Bone mineral mass is more closely related to LTM than to FTM, while annual changes in regional BMD are more closely correlated with changes in FTM in healthy postmenopausal women, and increased body weight is significantly associated with increased bone mineral mass.
Factors associated with 5-year risk of hip fracture in postmenopausal women.
This algorithm, based on 11 clinical factors, may be useful to predict the 5-year risk of hip fracture among postmenopausal women of various ethnic backgrounds and further studies are needed to assess the clinical implication of the algorithm in general and specifically to identify treatment benefits.
Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE
Variants in CADM2, a gene previously implicated in obesity, risk-taking behavior and other traits, were found to be associated with habitual PA, and genetic correlations of PA with other traits and diseases were found.
Fracture risk among breast cancer survivors: results from the Women's Health Initiative Observational Study.
Postmenopausal survivors of breast cancer are at increased risk for clinical fractures, and preventions and therapeutic interventions are needed to reduce fracture risk in this large and growing population.
Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative.
Use of PPIs was not associated with hip fractures but was modestly associated with clinical spine, forearm or wrist, and total fractures.
Hip fractures and heart failure: findings from the Cardiovascular Health Study.
AIMS The aim of the study was to find the epidemiology of hip fractures in heart failure. The increasing survival rate for patients with heart failure places them at risk for other diseases of