Zhanqi Zhao

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INTRODUCTION Lung protective ventilation requires low tidal volume and suitable positive end-expiratory pressure (PEEP). To date, few methods have been accepted for clinical use to set the appropriate PEEP. The aim of this study was to test the feasibility of PEEP titration guided by ventilation homogeneity using the global inhomogeneity (GI) index based on(More)
Potential harmful effects of ventilation therapy could be reduced by model-based predictions of the effects of ventilator settings to the patient. To obtain optimal predictions, the model has to be individualized based on patients' data. Given a nonlinear model, the result of parameter identification using iterative numerical methods depends on initial(More)
The electrical impedance tomography (EIT)-based global inhomogeneity (GI) index was introduced to quantify tidal volume distribution within the lung. Up to now, the GI index was evaluated for plausibility but the analysis of how it is influenced by various physiological factors is still missing. The aim of our study was to evaluate the influence of(More)
BACKGROUND Information on regional ventilation distribution in mechanically ventilated patients is important to develop lung protective ventilation strategies. In the present prospective animal study, we introduce an electrical impedance tomography (EIT)-based method to classify lungs into normally ventilated, overinflated, tidally recruited/derecruited and(More)
We hypothesized that not all patients with appreciably recruited lung tissue during a recruitment maneuver (RM) show significant improvement of oxygenation. In the present study, we combined electrical impedance tomography (EIT) with oxygenation measurements to examine the discrepancies of lung ventilation and perfusion versus oxygenation after RM.A(More)
The objective of this paper is to introduce and evaluate the adaptive SLICE method (ASM) for continuous determination of intratidal nonlinear dynamic compliance and resistance. The tidal volume is subdivided into a series of volume intervals called slices. For each slice, one compliance and one resistance are calculated by applying a least-squares-fit(More)
Amato [1] on our recent study [2], in which we proposed that ventilation inhomogeneity should be regarded as an additional prospective index along with blood gases, lung mechanics and hemodynamics in a multifactorial method to optimize positive end-expiratory pressure (PEEP) at the bedside. We agree with Costa and Amato that some ventilation heterogeneity(More)
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