Zhanna Kovalova

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BACKGROUND Acute lymphoblastic leukemia (ALL) is a complex disease caused by interactions between hazardous exogenous or/and endogenous agents and many mild effect inherited susceptibility mutations. Some of them are known, but their functional roles still requireinvestigation. Age is a recognized risk factor; children with disease onset after the age of(More)
INTRODUCTION Childhood acute lymphoblastic leukaemia (ALL) is a complex disease caused by a combination of genetic susceptibility and environmental exposure. Previous genome-wide association studies have reported several single nucleotide polymorphisms (SNPs) associated with the incidence of ALL. Several variations in genes encoding enzymes involved in(More)
OBJECTIVE The objective of this study was to investigate the prevalence of HCV (hepatitis C virus) infection in hemophilia patients in Latvia and to analyze association between natural clearance of HCV and human leukocyte antigen (HLA) class II genes. MATERIAL AND METHODS From 61 hemophilic patients participating in this study, 38 were adults and 23 were(More)
Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood (Tharnprisan et al., 2013). Its annual incidence rate is approximately 9-10 cases per 100.000 people in childhood, with peak incidence between the age of two and five years (J Yan et al., 2012). More than 80% of children diagnosed with ALL can be cured with current multiagent(More)
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