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Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma.
TLDR
It is demonstrated that IL-17 expression in airways is upregulated upon allergen inhalation, and constitutes the link between allergenic-induced T cell activation and neutrophilic influx. Expand
Clinical Features of COVID-19 Related Liver Damage
TLDR
SARS-CoV-2 may cause the liver function damage and the Lopinavir/ritonavir should be applied carefully for the treatment of COVID-19, which caused a prolonged length of stay in patients with emerging liver injury. Expand
A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease
TLDR
A consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease (pCD), based on best available evidence is developed. Expand
All‐trans retinoic acid down‐regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis
TLDR
RA down‐regulates colon inflammatory responses in patients with IBD in vitro and in murine colitis in vivo, representing a potential therapeutic approach in IBD treatment. Expand
IL-15 Is Highly Expressed in Inflammatory Bowel Disease and Regulates Local T Cell-Dependent Cytokine Production1
TLDR
It is indicated that IL-15 is overexpressed in the inflamed mucosa in IBD and thatIL-15 enhances local T cell activation, proliferation, and proinflammatory cytokine production by both T cells and macrophages, the latter via a CD40-CD40L interaction-dependent mechanism. Expand
Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases
TLDR
Recent progresses of SCFA in regulation of intestinal homeostasis as well as in pathogenesis of IBD are summarized. Expand
GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3
TLDR
The studies demonstrated that microbiota metabolites SCFA promoted IEC RegIIIγ and β-defensins in a GPR43-dependent manner, providing a novel pathway by which microbiota regulates IEC expression of AMP and intestinal homeostasis. Expand
miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD
TLDR
The data indicate that miR-10a is decreased in the inflamed mucosa of IBD and downregulates mucosal inflammatory response through inhibition of IL-12/IL-23p40 and NOD2 expression, and blockade of Th1/Th17 cell immune responses. Expand
The increased expression of IL‐23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity
TLDR
Data indicate that IL‐23 is highly expressed in inflamed mucosa of IBD and plays an important role in the induction of IEL, NK, and T cell activation, proinflammatory cytokine secretion, and Th17 cell differentiation. Expand
IL-25 Downregulates Th1/Th17 Immune Response in an IL-10–Dependent Manner in Inflammatory Bowel Disease
TLDR
IL-25 is markedly decreased in IBD and inhibits IBD CD4+ T-cell activation and differentiation into Th1/Th17 cells in an IL-10–dependent manner, suggesting that it may be a potential therapeutic agent for IBD. Expand
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