Zhan-Qi Cao

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Galectin-4, a tandem repeat member of the β-galactoside-binding proteins, possesses two carbohydrate-recognition domains (CRD) in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various(More)
A multifunctional bis-branched [1]rotaxane containing a perylene bisimide (PBI) core and two identical bistable[1]rotaxane arms terminated with ferrocene units was prepared and characterized by (1)H NMR, (13)C NMR, and 2D ROESY NMR spectroscopies and by HR-ESI spectrometry. The system is shown to possess several key features: (1) In acetone solution,(More)
A novel photo-responsive nano-container was successfully constructed based on well-defined vesicles formed by an amphiphilic overcrowded alkene switch. The nano-container could adjust its inner volume in reversible photo/heat controlled mode, which could show potential in remote drug delivery systems.
An acid/base responsive amphiphilic [2]rotaxane switch containing a hydrophilic macrocycle component and a hydrophobic terminal bulky group was prepared and characterized. The morphology of the supramolecular assemblies formed by the rotaxanes could be switched between spherical vesicles and worm-like micelles using acid/base stimuli, as confirmed by(More)
A fluorescent bistable [2]rotaxane terminated with an alkyne functional group was constructed and immobilized onto the surface of SiO2 nanoparticles through click reaction. The shuttling motion of the macrocycle component between two different stations was driven by external acid-base stimuli both in solution and on SiO2 nanoparticles, accompanied by visual(More)
SCOPE Although the previous trials of inflammation have indicated that morin hydrate (MO) hold considerable promise, understanding the distinct mechanism of MO against inflammation remains a challenge. METHODS AND RESULTS This study investigated the effect of MO in atherosclerosis in ApoE-/- mice and underlying cell signaling of MO effect in inflammation(More)
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