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  • Laura M. Cox, Shingo Yamanishi, Jiho Sohn, Alexander V. Alekseyenko, Jacqueline M. Leung, Ilseung Cho +9 others
  • 2014
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and(More)
For psoriasis, an idiopathic inflammatory disorder of the skin, the microbial biota has not been defined using cultivation-independent methods. We used broad-range 16S rDNA PCR for archaea and bacteria to examine the microbiota of normal and psoriatic skin. From 6 patients, 19 cutaneous samples (13 from diseased skin and 6 from normal skin) were obtained.(More)
Competing interests: The authors declare that they have no competing financial interests. Data and materials availability: 16S rRNA sequence data has been deposited to EBI with IDs ERA387449 and ERP008799. Abstract Most studies of the human microbiome have focused on westernized people with lifestyle practices that decrease microbial survival and(More)
  • Mei-ling A. Joiner, Olha M. Koval, Li Jingdong, B. Julie He, Chantal Allamargot, Zhan Gao +12 others
  • 2012
Myocardial cell death is initiated by excessive mitochondrial Ca(2+) entry causing Ca(2+) overload, mitochondrial permeability transition pore (mPTP) opening and dissipation of the mitochondrial inner membrane potential (ΔΨm). However, the signalling pathways that control mitochondrial Ca(2+) entry through the inner membrane mitochondrial Ca(2+) uniporter(More)
BACKGROUND Psoriasis is a common chronic inflammatory disease of the skin. We sought to characterize and compare the cutaneous microbiota of psoriatic lesions (lesion group), unaffected contralateral skin from psoriatic patients (unaffected group), and similar skin loci in matched healthy controls (control group) in order to discern patterns that govern(More)
This paper describes a virtual reality (VR) simulator, for the purpose of education, training and prototyping of telemanipulation of carbon nanotubes. Major challenges in interfacing a human operator with tasks of manipulating nanotubes via a haptic VR interface are outlined. After a review of previous efforts, we present the current state of our VR(More)
To determine whether protein tyrosine kinase (PTK) modulates volume-sensitive chloride current (I(Cl.vol)) in human atrial myocytes and to identify the PTKs involved, we studied the effects of broad-spectrum and selective PTK inhibitors and the protein tyrosine phosphatase (PTP) inhibitor orthovanadate (VO(4)(-3)). I(Cl.vol) evoked by hyposmotic bath(More)