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OBJECTIVE The present study was designed to observe the plasma concentrations of hydrogen sulfide (H(2)S) and homocysteine (HCY) in hypertensive patients with different blood pressure levels and complications. METHODS A total of 165 outpatients with essential hypertension were involved in this study (84 males, 81 females, mean age 59.81 +/- 10.60 years(More)
Hypertrophic cardiomyopathy is an autosomal-dominant disease. Disease-causing mutations have been found in genes encoding structural components of the thick and thin filament systems of cardiac myocyte; it has therefore been named as a disease of sarcomere. Many approaches have been used to characterize the pathogenesis of the disease. Transgenic animal(More)
AIMS Biventricular (BiV) pacing was superior to right ventricular apical (RVA) pacing at extended follow-up in the Pacing to Avoid Cardiac Enlargement (PACE) trial. Early pacing-induced systolic dyssynchrony (DYS) might be related to mid-term result. However, it remains unknown whether early pacing-induced DYS can predict long-term reduction of left(More)
OBJECTIVE To discuss the regulation of expression of cGMP-dependent protein kinase I(alpha) (PKG I(alpha)) by calcineurin (CaN) in vascular smooth muscle cells (VSMCs) proliferation. METHODS Cultured wistar rat aortic VSMCs were used as an experimental model. CaN was inhibited by its special inhibitor cyclosporin A (CsA). Phenylephrine (PE) was given to(More)
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