Zh Mihaylova

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PURPOSE To evaluate serum changes of matrix metalloproteinases (MMPs) 2 and 9, vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) levels in patients with advanced non-small cell lung cancer (NSCLC) and their association with main clinicopathological parameters during chemotherapy with cisplatin and gemcitabine. PATIENTS(More)
Colorectal cancer (CRC) is one of the most frequent malignancies, with more than 1,000,000 new cases annually worldwide and more than 4,000 new cases annually in Bulgaria. Liver metastases (LM) occur in more than 50% of CRC patients, but curative liver resection is possible only in 15% of them, resulting in 5-year survival rates of 30% on average. Improving(More)
PURPOSE Epidermal growth factor receptor-targeted monoclonal antibodies are active as monotherapy beyond second-line treatment. Skin toxicities (STs) are common during treatment, and a positive association between ST severity and patient outcome has been reported. This study collected information on panitumumab monotherapy use in patients with KRAS exon 2(More)
64 246 182 64 130 194 •Chemotherapy-induced febrile neutropenia (FN) is a well-known complication associated with increased morbidity and mortality and frequently leads to additional hospitalization 1-3; •Severe and prolonged neutropenia is associated with fever and infections that require systemic therapy (antibiotics, antimicotics etc); •Prophylactic use(More)
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