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Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.
A unique connection between MAS risk and chronic IL-18 is described, epithelial inflammasome hyperactivity is identified as a potential source, and the pathogenicity of free IL-16 is demonstrated, suggesting an IL- 18-driven pathway, complementary to the cytotoxic impairment of fHLH, with potential as a distinguishing biomarker and therapeutic target in MAS.
Immunization with Components of the Viral Fusion Apparatus Elicits Antibodies That Neutralize Epstein-Barr Virus in B Cells and Epithelial Cells.
Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria
A role of mitochondrial dysfunction in developing the premature aging phenotypes in HGPS cells is demonstrated and mitochondrial‐targeting antioxidant methylene blue is suggested as a promising therapeutic approach for HGPS.
Lamin A and microtubules collaborate to maintain nuclear morphology
It is found that LA knockout cells exhibit a crescent shape morphology associated with the microtubule-organizing center, which ameliorates upon treatment with MT drugs, Nocodazole or Taxol, and describes a collaborative effort between LA and the MT network to maintain nuclear morphology.
HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species
Synthetic lethality between decreased activity of cyclin-dependent kinases 4 and 6 and VHL inactivation is identified in two species (human and Drosophila) and across diverse human ccRCC cell lines in culture and xenografts.
Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine
- Zeshan Tariq, Nathan L Board, Alex Eftimiades, Ronnie M. Ibrahim
- Medicine, PsychologySAGE open medical case reports
- 1 January 2019
A patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine, hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology.
Epstein-Barr virus (EBV) hyperimmune globulin isolated from donors with high gp350 antibody titers protect humanized mice from challenge with EBV.
Methylene Blue Alleviates Nuclear and Mitochondrial Abnormalities in Hutchinson‐Gilford Progeria Syndrome
A role of mitochondrial dysfunction in developing the premature aging phenotypes in HGPS cells is demonstrated and a mitochondrial‐targeting antioxidant methylene blue is suggested as a promising therapeutic for HGPS.