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SUMMARY The large amount of data produced by proteomics experiments requires effective bioinformatics tools for the integration of data management and data analysis. Here we introduce a suite of tools developed at Vanderbilt University to support production proteomics. We present the Backup Utility Service tool for automated instrument file backup and the(More)
OBJECTIVE To investigate how the glucose variability between fasting and a 2-h postload glucose state (2-h postload plasma glucose [2hPG]-fasting plasma glucose [FPG]) is associated with chronic kidney disease (CKD) in middle-aged and elderly Chinese patients previously diagnosed with type 2 diabetes. DESIGN AND METHODS This cross-sectional study included(More)
OBJECTIVE To investigate the relationship between lipid profiles [including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)] and a mild decline in the estimated glomerular filtration rate (eGFR) in subjects with normal serum lipid levels. DESIGN AND METHODS In this(More)
OBJECTIVE To investigate whether fluctuations between the fasting and 2-h postload glucose ([2-hPBG]-fasting blood glucose [FBG]) states are associated with glomerular hyperfiltration (GHF) in middle-aged and elderly Chinese patients with newly diagnosed diabetes. DESIGN AND METHODS In this study, we included 679 newly diagnosed diabetes patients who were(More)
OBJECTIVE To investigate changes in the glycated hemoglobin A1c (A1c) level and those in β cell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients and to evaluate the relationship between them. DESIGN AND METHODS A total of 818 newly diagnosed diabetic individuals who were ≥ 40 years of age were recruited. The(More)
The large amount of data produced by proteomics experiments requires effective bioinformatics tools for the integration of data management and data analysis. Here we introduce a suite of tools developed at Vanderbilt University to support production proteomics. We present the Backup Utility Service tool for automated instrument file backup and the(More)
Background Shotgun proteomics is a powerful technology for protein identification in complex samples with remarkable applications in elucidating cellular and subcellular pro-teomes [1,2], and discovering disease biomarkers [3,4]. Shotgun proteomics data analysis usually relies on database search. Commonly used protein sequence databases in shotgun(More)
BACKGROUND Methionine aminopeptidase is a potential target of future antibacterial and anticancer drugs. Structural analysis of complexes of the enzyme with its inhibitors provides valuable information for structure-based drug design efforts. RESULTS Five new X-ray structures of such enzyme-inhibitor complexes were obtained. Analysis of these and other(More)
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