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Mucopolysaccharidoses (MPS) are a heterogeneous group of lysosomal storage disorders, due to deficiency of glycosaminoglycans breakdown enzymes. MPS type III is also known as SanFilippo syndrome, which is further subdivided into four distinct forms--A, B, C and D--caused by different enzyme deficiencies, but with similar clinical characteristics. Cardiac(More)
BACKGROUND Percutaneous transluminal treatment of a thrombotic vein graft yields poor results. We have previously reported our experience with transluminal percutaneous coronary ultrasound thrombolysis (CUT) in the setting of acute myocardial infarction (AMI). This report describes the first experience with ultrasound thrombolysis in thrombus-rich lesions(More)
Endothelin-1 and cyclic guanosine monophosphate (c-GMP) peripheral vein plasma levels increase during coronary angioplasty, but the reason for this increase has not been elucidated. The purpose of this study was to investigate whether these changes are related to myocardial ischaemia, or to mechanical artery injury induced during the procedure. Thirty-two(More)
BACKGROUND Controversy exists regarding inhibition of ischemic preconditioning in hyperlipidemic animals. In this study, we tested the hypothesis that hyperlipidemia inhibits the normal reduction of myocardial ischemia on repeated balloon inflations (BIs) during angioplasty. METHODS We studied 33 patients undergoing coronary angioplasty. All underwent a(More)
To investigate if the response of the contralateral artery during coronary angioplasty (PTCA) is different in hypertensive than in normotensive patients and whether this response is related to plasma levels of endothelin-1 (ET-1). We examined the change in ET-1 plasma levels and the reactivity of the left circumflex artery (LCx) during PTCA of the left(More)
BACKGROUND Bosentan, a dual endothelin receptor antagonist, has been used for symptomatic improvement of patients with idiopathic pulmonary arterial hypertension (PAH) and specific types of secondary (e.g. scleroderma and human immunodeficiency virus infection) PAH, but its efficacy in patients with congenital heart disease and chronic thromboembolic(More)
OxLDL uptake and cholesterol efflux inhibition in macrophages play a key role in atherosclerotic plaque formation, rupture, and thrombotic ischemia. This study investigates genes implicated in OxLDL uptake (CD36, SRA), cholesterol efflux inhibition (adipophilin, ADFP), and inflammatory recruitments of leukocytes (IL-8) in plaque lesion areas (PLAs) compared(More)