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The invariant characteristic features associated with Alzheimer's disease (AD) brain include the presence of extracellular neuritic plaques composed of amyloid beta (Abeta) peptide, intracellular neurofibrillary tangles containing hyper-phosphorylated tau protein and the loss of basal forebrain cholinergic neurons. Studies of the pathological changes that(More)
The antiobiotics, diumycin, amphomycin, bacitracin, and showdomycin have been shown previously to block the synthesis of GlcNAc-P-P-dolichol and GlcNAc-GlcNAc-P-P-dolichol. In view of inconsistencies in the literature concerning the sites of inhibition, we have reinvestigated the influence of these drugs on the formation of these early intermediates of the(More)
In mammalian cells newly synthesized lysosomal proteins are targeted to lysosomes by two different mechanisms. Mannose-6-phosphate residues are transferred to soluble lysosomal hydrolases during their passage through the Golgicomplex. In the Trans-Golgi-Network specific receptors recognize these carbohydrate markers. The receptor ligand complexes are sorted(More)
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