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14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination
14-3-3 proteins specifically bound 5′-AGCT-3′ repeats, were upregulated in B cells undergoing CSR and were recruited with AID to the switch regions that are involved in CSR events (Sμ→Sγ1, Sμ→ Sγ3 or S μ→Sα). Expand
Down-regulation of 14-3-3ζ suppresses anchorage-independent growth of lung cancer cells through anoikis activation
  • Zenggang Li, J. Zhao, +6 authors H. Fu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 8 January 2008
A critical role is revealed in anoikis suppression in lung cancer cells, and 14-3-3ζ is identified and validates as a potential molecular target for anticancer therapeutic development. Expand
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis
A large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals finds 16 SNPs within 15 new genes/loci associated with Psoriasis, and duplicates four known susceptibility loci TNIP1, NFKBIA, IL12B and LCE3D–LCE3E. Expand
14-3-3ζ Mediates Resistance of Diffuse Large B Cell Lymphoma to an Anthracycline-based Chemotherapeutic Regimen
Patients presenting with diffuse large B cell lymphoma (DLBCL) are treated with a standard anthracycline-based chemotherapeutic mixture consisting of cyclophosphamide, doxorubicin, vincristine, andExpand
Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway
This work identifies nuclear PRAS40 as a dual-input signaling checkpoint that links cell growth and proliferation to inhibition of cellular senescence and identifies thePRAS40–RPL11 complex as a promising target for p53-restorative anticancer drug discovery. Expand
Corrigendum: The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
This work presents a new probabilistic procedure that allows for direct measurement of the response of the immune system to EMTs and shows real-time recognition of EMT activity in the response to EMMARM. Expand
The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
The generation of a cancer-focused PPI network, termed OncoPPi, and identification of >260 cancer-associated PPIs not in other large-scale interactomes are reported, which reveal new regulatory mechanisms for cancer genes like MYC, STK11, RASSF1 and CDK4. Expand
Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3
This work reports a novel regulatory mechanism that controls the dynamic status of p21 through its interaction with Cdk5 and Abl enzyme substrate 1 (Cables1), and suggests Cables1 as a novel p21 regulator through maintaining p21 stability. Expand
Cables1 complex couples survival signaling to the cell death machinery.
Together, the results illuminated a dynamic regulatory system through which activated Akt and 14-3-3 work directly together to neutralize a potent tumor suppressor function of Cables1. Expand
Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform.
  • Xiulei Mo, Yin Luo, +6 authors H. Fu
  • Computer Science, Medicine
  • Journal of molecular cell biology
  • 1 June 2016
The development and integration of a highly sensitive NanoLuc luciferase-based bioluminescence resonance energy transfer technology, termed BRET(n), which enables ultra-high-throughput (uHTS) PPI detection in live cells with streamlined co-expression of biosensors in a miniaturized format is described. Expand