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Flow of Cortical Activity Underlying a Tactile Decision in Mice
A motor cortex circuit for motor planning and movement
The conversion of preparatory activity to movement within a structured motor cortex circuit is dissected and it is shown that layer 5 neurons projecting within the cortex have unbiased laterality.
Procedures for Behavioral Experiments in Head-Fixed Mice
Perceptual performance correlated with the degree of water restriction, supporting the importance of controlling access to water, and behavioral training for head-fixed mice, with a focus on active, whisker-based tactile behaviors.
Maintenance of persistent activity in a frontal thalamocortical loop
- Zengcai V. Guo, Hidehiko K. Inagaki, Kayvon Daie, S. Druckmann, C. Gerfen, K. Svoboda
- Biology, PsychologyNature
- 4 April 2017
The results show that the thalamus is a circuit hub in motor preparation and suggest that persistent activity requires reciprocal excitation across multiple brain areas.
Optical interrogation of neural circuits in Caenorhabditis elegans
It is demonstrated that one can excite specific neurons expressing ChR2 while simultaneously monitoring G-CaMP fluorescence in several other neurons, making it possible to rapidly decipher functional connections in C. elegans neural circuits.
Controlling interneuron activity in Caenorhabditis elegans to evoke chemotactic behavior
Optogenetics and new optical tools are used to manipulate neural activity directly in freely moving animals to evoke chemotactic behaviour and it is discovered that controlling the dynamics of activity in just one interneuron pair (AIY) was sufficient to force the animal to locate, turn towards and track virtual light gradients.
Neural coding during active somatosensation revealed using illusory touch
These results show that mice integrate coding of touch with movement over timescales of a whisking bout to produce perception of active touch, and reduce activity biased behavior, consistent with a spike count code for object detection at a particular location.
Spatiotemporal constraints on optogenetic inactivation in cortical circuits
This work benchmarked several optogenetic methods to inactivate small regions of neocortex and offered guidance for the design of in vivo optogenetics experiments.
Erratum: Procedures for Behavioral Experiments in Head-Fixed Mice (PLoS ONE (2014) 9, 2 (e88678) DOI:10.1371/journal.pone.0088678)