Learn More
The trp operon encodes the five genes for the enzymes required to convert chorismate to tryptophan, and its switching on and off is controlled by both feedback repression and attenuation in response to different levels of tryptophan in the cell. Repression of the operon occurs when tryptophan concentration is high, and attenuation fine-tunes the(More)
The Escherichia coli DegP has been reported to function both as molecular chaperone and protease for the quality control of outer membrane protein biogenesis. Activation of the inactive DegP hexamers was believed to occur via their disassembly into trimeric units and subsequent reassembly into larger oligomers (12-mers and 24-mers). Here, we analyzed the(More)
Small heat shock proteins (sHSPs) are molecular chaperones ubiquitously present in all forms of life, but their function mechanisms remain controversial. Here we show by cryo-electron microscopy and single particle 3D reconstruction that, at the low temperatures (4-25°C), CeHSP17 (a sHSP from Caenorhabditis elegans) exists as a 24-subunit spherical oligomer(More)
Bacterial persisters, usually being considered as dormant cells that are tolerant to antibiotics, are an important source for recurrent infection and emergence of antibiotic resistant pathogens. Clinical eradication of pathogenic persisters is highly desired but greatly difficult mainly due to the substantial reduction in antibiotics uptake as well as the(More)
The ATP synthase (having a typical subunit composition of α3β3γδεab2c8-15) employs an intriguing rotary mechanism for the generation of ATP from ADP and Pi, using energy stored in a transmembrane proton gradient. The conventional rotary model, although being generally accepted, remains difficult to explain certain experimental observations. Here we propose(More)
This special issue commemorates the 90th anniversary (19252015) of Peking University's School of Life Sciences. As one of China's centers for education and research in biological sciences, the school's past 90 years have been eventful, ranging from times of prosperity to periods of war and chaos, with numerous outstanding students launching distinguished(More)
Citation: Chang, Z. (2016). The discovery of Qinghaosu (artemisinin) as an effective anti-malaria drug: A unique China story. In a collective effort to find new drugs for killing the malaria parasites (plasmodium) that became resistant to the conventional drugs such as chloroquine, scientists in China not only rediscovered the anti-malaria effect of the(More)
Citation: Chang ZY, Gu LC. Is the mission to identify all the human proteins achievable?—Commenting on the human proteome draft maps. Unveiling the structure and function of all the proteins a human body produces is undoubtedly a key task for us to better understand ourselves. Although a mission difficult to achieve, this apparently becomes more feasible(More)
Some 600 scholars and students in protein science from around 40 institutions across China gathered at the 4th Symposium of the Chinese Protein Society held during Oc-tober 1214, 2013, in the city of Hefei, Anhui Province, China, with the theme " Protein and Human Health ". The topics of this symposium covered almost all areas in protein science, from(More)
  • 1