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目的基于中药质量标志物(Q-Marker)理念,使用UPLC-Q Exactive四级杆-静电场轨道阱高分辨液质联用技术,对清热灵颗粒主要化学成分进行快速识别和鉴定,建立清热灵颗粒的潜在Q-Marker库,为探讨建立中成药清热灵颗粒的系统质量控制方法奠定基础。 方法以50%甲醇作为提取液制备供试液,采用ACQUITY UPLC BEH C18色谱柱(100 mm×2.1 mm,1.7(More)