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Human Umbilical Vein-Derived Dopaminergic-Like Cell Transplantation with Nerve Growth Factor Ameliorates Motor Dysfunction in a Rat Model of Parkinson’s Disease
TLDR
The results suggest that transplantation of the dopaminergic-like cells combined with NGF administration may represent a new strategy of stem cell therapy for PD.
The influence of thymectomy on Germ-cells of the testis in mice
TLDR
Thymus and its hormone stimulated not only the mitotic division, but also the meiotic division of germ cells during spermatogenesis, suggesting that thymus-sexual axis may play an important role in the process of sperMatogensis in the testis.
Effects of tetrahydroxystilbene glucoside on hypoxia inducible factor-1 alpha and erythropoietin in old rat after cerebral ischemia reperfusion
TLDR
TSG can improve the neurological function through increasing the expressions of HIF-1a and EPO of cerebral ischemia-reperfusion old rats through increase the protein expressions in the cortex after reperfusion.
Antidepressant-like and anxiolytic-like effects of YL-IPA08, a potent ligand for the translocator protein (18 kDa)
TLDR
Results indicate that YL-IPA08 is a more potent and selective TSPO ligand, which exerts antidepressant-like and anxiolytic-like effects on behaviors that are mediated by T SPO but does not cause the side effects that are typically associated with conventional benzodiazepines.
Antidepressant-like effects of 071031B, a novel serotonin and norepinephrine reuptake inhibitor
TLDR
It is suggested that 071031B is a novel, balanced serotonin and norepinephrine reuptake inhibitor, with more potent antidepressant effects and lower hepatotoxicity and neurotoxicity in vitro than duloxetine.
Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function
TLDR
It is suggested that immobility duration depends on 5-HT transporter binding levels, which lead to apparent strain differences in immobilities time in the FST and TST.
The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity
TLDR
It is demonstrated that Yuanzhi-1 has a potential to be a novel triple monoamine reuptake inhibitor of antidepressant-like activity.
Antidepressant-Like Activity of YL-0919: A Novel Combined Selective Serotonin Reuptake Inhibitor and 5-HT1A Receptor Agonist
TLDR
It is suggested that YL-0919, a novel structure compound, exerts dual effect on the serotonergic system, as both 5-HT1A receptor agonist and 5- HT uptake blocker, showing remarkable antidepressant effects in animal models, and may be used as a new option for the treatment of major depressive disorder.
The antidepressant-like pharmacological profile of Yuanzhi-1, a novel serotonin, norepinephrine and dopamine reuptake inhibitor
TLDR
In vivo microdialysis studies showed that 5- and 10-mg/kg administrations of Yuanzhi-1 significantly increased the extracellular concentrations of 5-HT, NE and DA in the frontal cortices of freely moving rats and might represent a novel triple reuptake inhibitor and possess antidepressant-like activity.
The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: Serotonin, norepinephrine and dopamine reuptake inhibitor
TLDR
It is shown for the first time that FAE is a novel triple inhibitor of monoamine transporters, which may be one the mechanisms of its antidepressant activity.
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