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Mitochondrial antiviral signaling protein (MAVS) is an essential component of virus-activated signaling pathways that induce protective IFN responses. Its localization to the outer mitochondrial membrane suggests an important yet unexplained role for mitochondria in innate immunity. Here, we show that hepatitis A virus (HAV), a hepatotropic picornavirus,(More)
Three dimensional (3D) wireless sensor networks have attracted a lot of attention due to its great potential usages in both commercial and civilian applications. Topology control in 3D sensor networks has been studied recently. Different 3D geometric topologies were proposed to be the underlying network topologies to achieve the sparseness of the(More)
Oncogene activation in tumor cells induces broad and complex cellular changes that contribute significantly to disease initiation and progression. In melanoma, oncogenic BRAF(V600E) has been shown to drive the transcription of a specific gene signature that can promote multiple mechanisms of immune suppression within the tumor microenvironment. We show here(More)
For retroviruses such as HIV-1 and murine leukemia virus (MLV), active receptor recruitment and trafficking occur during viral entry. However, the underlying mechanisms and cellular factors involved in the process are largely uncharacterized. The viral receptor for ecotropic MLV (eMLV), a classical model for retrovirus infection mechanisms and pathogenesis,(More)
The structural relaxation of a glass forming liquid, methyl m-toluate, is studied in the deeply supercooled region near glass transition with the calorimetric and dielectric techniques. The thermodynamics and kinetics of the enthalpy relaxation are focused, and the kinetic studies are paralleled with dielectric relaxation. Relaxation enthalpies are(More)
The HIV-1 protease has proven to be a crucial component of the HIV replication machinery and a reliable target for anti-HIV drug discovery. In this study, we applied an optimized hierarchical multistage virtual screening method targeting HIV-1 protease. The method sequentially applied SVM (Support Vector Machine), shape similarity, pharmacophore modeling(More)
Three-dimensional (3D) wireless sensor networks have attracted a lot of attention due to their great potential usages in both commercial and civilian applications, such as environmental data collection, pollution monitoring, space exploration, disaster prevention, and tactical surveillance. Topology control in 3D sensor networks has been studied recently,(More)
The dielectric relaxations in six primary and secondary alkoxy alcohols with varying molecular size and different separation between -O- and hydroxyl group are studied at temperatures around glass transition. The analyses of the apparent full width at half maximum of the main relaxations of the alkoxy alcohols reveal minima in the temperature dependence of(More)
A quantitative evaluation of the contribution of mixing thermodynamics to glass transition is performed for a binary eutectic benzil and m-nitroaniline system. The microcalorimetric measurements of the enthalpy of mixing give small and positive values, typically ~200 J mol(-1) for the equimolar mixture. The composition dependence of the glass transition(More)
The dielectric strength of the Debye relaxation in the binary mixtures of two isomeric monohydroxy alcohols, 2-ethyl-1-butanol (2E1B) and 4-methyl-2-pentanol (4M2P), is studied at low temperature near glass transition. Enhanced dielectric strength is exhibited in the mixtures, remarkably different from the mixing behaviors of the structural (α-) relaxation(More)