Zeljka Minic

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Previously we have shown that adenosine operating via the A(1) receptor subtype may inhibit glutamatergic transmission in the baroreflex arc within the nucleus of the solitary tract (NTS) and differentially increase renal (RSNA), preganglionic adrenal (pre-ASNA), and lumbar (LSNA) sympathetic nerve activity (ASNA>RSNA≥LSNA). Since the cardiopulmonary(More)
Adenosine is a powerful central neuromodulator acting via opposing A1 (inhibitor) and A2a (activator) receptors. However, in the nucleus of the solitary tract (NTS), both adenosine receptor subtypes attenuate cardiopulmonary chemoreflex (CCR) sympathoinhibition of renal, adrenal, and lumbar sympathetic nerve activity and attenuate reflex decreases in(More)
Previously we have shown that stimulation of inhibitory A1 adenosine receptors located in the nucleus tractus solitarii (NTS) attenuates cardiopulmonary chemoreflex (CCR) evoked inhibition of renal, adrenal and lumbar sympathetic nerve activity and reflex decreases in arterial pressure and heart rate. Activation of facilitatory A2a adenosine receptors,(More)
Selective stimulation of inhibitory A1 and facilitatory A2a adenosine receptor subtypes located in the nucleus of the solitary tract (NTS) powerfully inhibits cardiopulmonary chemoreflex (CCR) control of regional sympathetic outputs via different mechanisms: direct inhibition of glutamate release and facilitation of an inhibitory neurotransmitter release,(More)
Drug delivery to the central nervous system (CNS) is challenging due to the inability of many drugs to cross the blood-brain barrier (BBB). Here, we show that wheat germ agglutinin horse radish peroxidase (WGA-HRP) chemically conjugated to gold nanoparticles (AuNPs) can be transported to the spinal cord and brainstem following intramuscular injection into(More)
<lb>PRECLINICAL EVALUATION OF INFRARED LIGHT THERAPY IN A RAT MODEL<lb>OF NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY<lb>by<lb>CHRISTIAN ANDREW REYNOLDS<lb>August 2015<lb>Advisor: Drs. Karin Przyklenk and Thomas Sanderson<lb>Major: Physiology<lb>Degree: Doctor of Philosophy<lb>This work has provided two major technical contributions to the field of(More)
UNLABELLED Respiratory complications in patients with spinal cord injury (SCI) are common and have a negative impact on the quality of patients' lives. Systemic administration of drugs that improve respiratory function often cause deleterious side effects. The present study examines the applicability of a novel nanotechnology-based drug delivery system,(More)
<lb>MECHANISMS MEDIATING MODULATION OF CARDIOPULMONARY<lb>CHEMOREFLEX CONTROL OF REGIONAL SYMPATHETIC ACTIVITY BY<lb>ADENOSINE A1 and A2a RECEPTORS LOCATED IN THE NTS<lb>by<lb>ZELJKA MINIC<lb>August 2013<lb>Advisor: Dr. Tadeusz J. Scislo<lb>Major: Physiology<lb>Degree: Doctor of Philosophy<lb>Adenosine is an important neuromodulator of cardiovascular(More)
Respiratory complications in patients with spinal cord injury (SCI) are common and can have a negative impact on the quality of patients' lives. Previously, we found that intradiaphragmatic administration of the nanoconjugate-bound A1 adenosine receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) induced recovery of diaphragm function following(More)
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