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Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes
Background— Distinct subpopulations of L-type calcium channels (LTCCs) with different functional properties exist in cardiomyocytes. Disruption of cellular structure may affect LTCC in aExpand
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Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line
The role of mechanosensitive (MS) Ca2+-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function and life-threatening thrombus formation. WeExpand
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Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.
BACKGROUND Pulmonary arterial hypertension (PAH) results in right ventricular (RV) failure, electro-mechanical dysfunction and heightened risk of sudden cardiac death (SCD), although exact mechanismsExpand
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OP16 Hydrogen sulfide inhibits human platelet aggregation
Platelets are critically involved in both haemostasis and thrombosis and are a major therapeutic target in the treatment of thrombotic disorders such as myocardial infarction. Platelets are regulatedExpand
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P2X1 Receptors Amplify FcγRIIa-Induced Ca 2+ Increases and Functional Responses in Human Platelets
Platelets express key receptors of the innate immune system such as FcγRIIa and Toll-like receptors (TLR). P2X1 cation channels amplify the platelet responses to several major platelet stimuli,Expand
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The Mitochondrial Translocator Protein and the Emerging Link Between Oxidative Stress and Arrhythmias in the Diabetic Heart
The mitochondrial translocator protein (TSPO) is a key outer mitochondrial membrane protein that regulates the activity of energy-dissipating mitochondrial channels in response to oxidative stress.Expand
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Abstract 11593: Thrombus Formation Under Flow is Inhibited by the Mechanosensitive Cation Channel Blockers GsMTx-4 Peptide and Gadolinium Chloride
Introduction: Ion channels contribute significantly to platelet physiology, including control of Ca2+ as a second messenger. Although there is a clear link between platelet activation and shear str...
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Evidence for shear mediated Ca 2 + entry through mechanosensitive cation
Ilkan, Z., Wright, J. R., Goodall, A. H., Gibbins, J. M., Jones, C. I. and Mahaut­Smith, M. P. (2017) Evidence for shear­ mediated Ca2+ entry through mechanosensitive cation channels in humanExpand
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Optical Action Potential Mapping in Acute Models of Ischemia-Reperfusion Injury: Probing the Arrhythmogenic Role of the Mitochondrial Translocator Protein.
Ischemia-reperfusion (I/R) injury causes dynamic changes in electrophysiological properties that promote the incidence of post-ischemic arrhythmias. High-resolution optical action potential mappingExpand
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Immobilization of Nonactivated Unfixed Platelets for Real-Time Single-Cell Analysis.
Existing methods for measuring the response of individual platelets to stimulation are limited. They either measure each platelet at one discrete time-point (flow cytometry) or rely on adhesiveExpand
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