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Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes
Background— Distinct subpopulations of L-type calcium channels (LTCCs) with different functional properties exist in cardiomyocytes. Disruption of cellular structure may affect LTCC in a… Expand
Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line
- Zeki Ilkan, J. R. Wright, A. Goodall, J. Gibbins, C. Jones, M. Mahaut-Smith
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 17 April 2017
The role of mechanosensitive (MS) Ca2+-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function and life-threatening thrombus formation. We… Expand
Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.
- Benjamin Strauss, Y. Sassi, +9 authors F. Akar
- Journal of molecular and cellular cardiology
- 1 February 2019
BACKGROUND Pulmonary arterial hypertension (PAH) results in right ventricular (RV) failure, electro-mechanical dysfunction and heightened risk of sudden cardiac death (SCD), although exact mechanisms… Expand
OP16 Hydrogen sulfide inhibits human platelet aggregation
Platelets are critically involved in both haemostasis and thrombosis and are a major therapeutic target in the treatment of thrombotic disorders such as myocardial infarction. Platelets are regulated… Expand
P2X1 Receptors Amplify FcγRIIa-Induced Ca 2+ Increases and Functional Responses in Human Platelets
- Zeki Ilkan, S. Watson, S. Watson, M. Mahaut-Smith
- Chemistry, Medicine
- Thrombosis and haemostasis
- 29 January 2018
Platelets express key receptors of the innate immune system such as FcγRIIa and Toll-like receptors (TLR). P2X1 cation channels amplify the platelet responses to several major platelet stimuli,… Expand
The Mitochondrial Translocator Protein and the Emerging Link Between Oxidative Stress and Arrhythmias in the Diabetic Heart
The mitochondrial translocator protein (TSPO) is a key outer mitochondrial membrane protein that regulates the activity of energy-dissipating mitochondrial channels in response to oxidative stress.… Expand
Abstract 11593: Thrombus Formation Under Flow is Inhibited by the Mechanosensitive Cation Channel Blockers GsMTx-4 Peptide and Gadolinium Chloride
Introduction: Ion channels contribute significantly to platelet physiology, including control of Ca2+ as a second messenger. Although there is a clear link between platelet activation and shear str...
Evidence for shear mediated Ca 2 + entry through mechanosensitive cation
Ilkan, Z., Wright, J. R., Goodall, A. H., Gibbins, J. M., Jones, C. I. and MahautSmith, M. P. (2017) Evidence for shear mediated Ca2+ entry through mechanosensitive cation channels in human… Expand
Optical Action Potential Mapping in Acute Models of Ischemia-Reperfusion Injury: Probing the Arrhythmogenic Role of the Mitochondrial Translocator Protein.
Ischemia-reperfusion (I/R) injury causes dynamic changes in electrophysiological properties that promote the incidence of post-ischemic arrhythmias. High-resolution optical action potential mapping… Expand
Immobilization of Nonactivated Unfixed Platelets for Real-Time Single-Cell Analysis.
Existing methods for measuring the response of individual platelets to stimulation are limited. They either measure each platelet at one discrete time-point (flow cytometry) or rely on adhesive… Expand