Zehuan Huang

  • Citations Per Year
Learn More
We describe a new strategy to control the reactivity of SeSe bond by using supramolecular chemistry of cucurbituril. We have demonstrated that selenocystamine (SeCy) and cucurbit[6]uril (CB[6]) can form a stable supramolecular complex (Ka =5.5×10(6)  M(-1) ). Before complexation, the free SeSe bond in SeCy is rather sensitive to redox stimuli and gets(More)
A new method in which supramolecular polymerization is promoted and controlled through self-sorting is reported. The bifunctional monomer containing p-phenylene and naphthalene moieties was prepared. Supramolecular polymerization is promoted by selective recognition between the p-phenylene group and cucurbit[7]uril (CB[7]), and 2:1 complexation of the(More)
This work is aimed at providing a supramolecular strategy for tuning the cytotoxicity in chemotherapy. To this end, as a proof of concept, we employed dynamic cucurbit[7]uril(CB[7])-mediated host-guest interaction to control the loading and releasing of dimethyl viologen (MV) as a model antitumor agent. MV has high cytotoxicity to both normal cells and(More)
Supramolecular chemotherapy is aimed to employ supramolecular approach for regulating the cytotoxicity and improving the efficiency of antitumor drugs. In this paper, we demonstrated a new example of supramolecular chemotherapy by utilizing the clinical antitumor drug, oxaliplatin, which is the specific drug for colorectal cancer treatment. Cytotoxicity of(More)
A redox-responsive hybrid of polyoxometalate and conducting oligomer including its self-assemblies with controllable morphologies are reported. To this end, a hybrid molecule, containing a Lindqvist hexamolybdate as the polar head group and N,N'-bis(4'-amino-2,6-dimethylphenyl)-1,4-quinonediimine as the redox-responsive and aggregating group, is prepared.(More)
A new method of supramolecular polymerization at the water-oil interface is developed. As a demonstration, an oil-soluble supramonomer containing two thiol end groups linked by two ureidopyrimidinone units and a water-soluble monomer bearing two maleimide end groups are employed. Supramolecular interfacial polymerization can be implemented by a(More)
This communication is aimed to introduce a new method of controllable supramolecular polymerization through kinetic trapping. To this end, two bifunctional monomers with cucurbit[7]uril (CB[7]) and adamantane end groups were synthesized. The CB[7]-containing monomer was pre-saturated with a pH-responsive competitive guest for kinetic control. Then, the(More)
Linear supramolecular polymers were obtained in aqueous solution by employing cucurbit[8]uril-based host-guest interaction as the driving force. Water-soluble monomers were prepared through direct metal-coordination. The rigid and bulky terpyridine-Fe linker can effectively enhance the monomer's solubility and suppress its cyclization, thereby promoting(More)
High efficacy and low toxicity are critical for cancer treatment. Polyoxometalates (POMs) have been reported as potential candidates for cancer therapy. On accounts of the slow clearance of POMs, leading to long-term toxicity, the clinical application of POMs in cancer treatment is restricted. To address this problem, a degradable organoimido derivative of(More)
Rational control of the cooperativity of multiple noncovalent interactions often plays an important role in the design and construction of supramolecular self-assemblies and materials, especially in precision supramolecular engineering. However, it still remains a challenge to control the cooperativity of multiple noncovalent interactions through tuning the(More)