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OBJECTIVE MicroRNAs (miRNAs) are non-coding, single-stranded small RNAs that regulate gene expression negatively, which is involved in fundamental cellular processes and the initiation, development and progression of human cancer. In this study, we investigated the role of miR-27a in the development of drug resistance in ovarian cancer cells. METHODS(More)
OBJECTIVE Individuals with Fanconi anemia (FA) are predisposed to develop ovarian cancer than those without FA, this is largely contributed to promoter methylation of the FANCF gene and subsequent disruption of the FA-BRCA pathway. In an attempt to understand more molecular genetic bases of ovarian cancer, we examined the expression of the FANCF and the(More)
Enhancer of Zeste Homologue 2 (EZH2), a specific histone 3 lysine 27 (H3K27) methyltransferase, plays a critical role in tumorigenesis and cancer progression through epigenetic gene silencing and chromatin remodeling. However, the role of EZH2 in chemotherapy resistance is unknown. In this study, we found that EZH2 was overexpressed in cisplatin-resistant(More)
BACKGROUND Women aged >or=65 years are screened routinely for osteoporosis in the developed world and identifying risk factors for osteoporosis should be highlighted in developing countries such as the People's Republic of China. In the present study, possible factors related to the occurrence of primary osteoporosis in aged Chinese women were explored. (More)
—The link quality variation of wireless channels has been a challenging issue in data communications until recent explicit exploration in utilizing this characteristic. The same broadcast transmission may be perceived significantly differently, and usually independently, by receivers at different geographic locations. Furthermore, even the same stationary(More)
—The current wireless cellular networks can be used to provide machine-to-machine (M2M) communication services. However, the Long Term Evolution (LTE) networks, which are designed for human users, may not be able to handle a large number of bursty random access requests from machine-type communication (MTC) devices. In this paper, we propose a scheme that(More)
—Opportunistic data forwarding (ODF) has drawn much attention in wireless networking research in recent years. The effectiveness of ODF in wireless networks is heavily depended on the choice of proper routing protocols which can provide effective source routing services. In this paper, we propose a new routing protocol named PSR for ODF in mobile ad-hoc(More)
—Opportunistic data forwarding has drawn much attention in the research community of multihop wireless networking , with most research conducted for stationary wireless networks. One of the reasons why opportunistic data forwarding has not been widely utilized in mobile ad hoc networks (MANETs) is the lack of an efficient lightweight proactive routing(More)
—opportunistic data forwarding draws more and more attention in the research community of wireless network after the initial work ExOR was published. However, as far as we know, all existing opportunistic data forwarding only use the nodes which are included in the forwarder list in the entire forwarding progress. In fact, even if a node is not a listed(More)