Zeguang Zheng

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BACKGROUNDS Bone morphogenetic protein receptor type 2 (BMPR2) signaling is anti-inflammatory. Decreased BMPR2 expression was seen in lung tissue from chronic obstructive pulmonary disease (COPD) patients. METHODS The selected single nucleotide polymorphisms (SNPs) in BMPR2 were genotyped with polymerase chain reaction (PCR) ligase detection reaction. The(More)
Mucin MUC4, which is encoded by the MUC4 gene, plays an important role in epithelial cell proliferation and differentiation. Aberrant MUC4 overexpression is associated with invasive tumor proliferation and poor outcome in epithelial cancers. Collectively, the existing evidence suggests that MUC4 has tumor-promoter functions. In this study, we performed a(More)
BACKGROUND Poor adherence leads to a high rate of exacerbation and poor health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD). However, few strategies are acceptable and effective in improving medication adherence. We investigated whether pharmaceutical care by clinical pharmacists could reinforce medication(More)
The purpose of this paper is to improve mel frequency cepstrum coefficients (MFCCs) for cough recognition. To highlight high energy, the most remarkable characteristic of cough sound, we propose a method of sub-band energy transformation to improve traditional MFCCs. This method enhances bands with high energy and ignores the ones with low energy according(More)
BACKGROUND GIRD COPD Biobank is a multicenter observational study blood-based database with local characteristics, in order to investigate the causes, risk factors, pathogenesis, prevalence patterns and trends of COPD and promote new pathogenic insights in China. METHODS We enrolled 855 clinically COPD patients and 660 controls with normal lung function.(More)
Dynamic lung sound signal analysis and processing require synchronous multi-channel data acquisition system. In noninvasive and no pain lung sound diagnosis system, the highly accurate, synchronous and stable data acquisition system is the foundation of fellow-up work. In order to acquire the array data of lung sound, higher speed, reliability and(More)
BACKGROUND This study is to explore the components and related mechanism responsible for the increase of work of breathing (WB) in chronic obstructive pulmonary disease (COPD) patients. METHODS Eight COPD patients and eight healthy volunteers were recruited in the study. The rebreathing method was used to increase end-tidal CO2 partial pressure (PetCO2)(More)
BACKGROUND Convincing evidences have demonstrated the associations between HHIP and FAM13a polymorphisms and COPD in non-Asian populations. Here genetic variants in HHIP and FAM13a were investigated in Southern Han Chinese COPD. METHODS A case-control study was conducted, including 989 cases and 999 controls. The associations between SNPs genotypes and(More)
OBJECTIVE To establish a method to detect aspiration of nasopharyngeal secretion and to explore the relationship between aspiration of nasopharyngeal secretion and pneumonia. METHOD Thirty-two patients with pulmonary infection [(30 males, 2 females; mean age (73 ± 8) years] were recruited from the First Affiliated Hospital of Guangzhou Medical University(More)