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The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway. The TEAD family of transcription factors binds directly to and mediates YAP-induced gene expression. Here we report the three-dimensional structure of the YAP (residues 50-171)-TEAD1(More)
In mobile ad hoc networks (MANETs), tasks are conducted based on the cooperation of nodes in the networks. However, since the nodes are usually constrained by limited computation resources, selfish nodes may refuse to be cooperative. Reputation systems and price-based systems are two main solutions to the node noncooperation problem. A reputation system(More)
Since centralized data storage and search schemes often lead to high overhead and latency, distributed data-centric storage becomes a preferable approach in large-scale wireless sensor networks (WSNs). However, most of existing distributed methods lack optimization for spatial-temporal search to query events occurred in a certain geographical area and a(More)
TET proteins oxidize 5-methylcytosine (5mC) on DNA and play important roles in various biological processes. Mutations of TET2 are frequently observed in myeloid malignance. Here, we present the crystal structure of human TET2 bound to methylated DNA at 2.02 Å resolution. The structure shows that two zinc fingers bring the Cys-rich and DSBH domains together(More)
Video sharing has been an increasingly popular application in online social networks (OSNs). However, its sustainable development is severely hindered by the intrinsic limit of the client/server architecture deployed in current OSN video systems, which is not only costly in terms of server bandwidth and storage but also not scalable with the soaring amount(More)
The explosive growth of unsolicited emails has prompted the development of numerous spam filtering techniques. A Bayesian spam filter is superior to a static keywordbased spam filter because it can continuously evolve to tackle new spam by learning keywords in new spam emails. However, Bayesian spam filters can be easily poisoned by avoiding spam keywords(More)
Mobile ad hoc networking works properly only if mobile nodes cooperate in routing. However, since wireless mobile nodes are usually constrained by limited power and computation resources, some selfish nodes may refuse to forward packets which are not of their direct interest. Most previous efforts counter this behavior by having each node keep a reputation(More)
This paper addresses the data search problem in large-scale highly mobile and dense wireless networks. Current wireless network data search systems are not suitable for large-scale highly mobile and dense wireless networks. This paper presents a scalable and mobility-resilient LOcality-based distRibuted Data search system (LORD) for large-scale wireless(More)
DNA methylation is an important epigenetic modification. Ten-eleven translocation (TET) proteins are involved in DNA demethylation through iteratively oxidizing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Here we show that human TET1 and TET2 are more active on 5mC-DNA than 5hmC/5fC-DNA(More)