Zdenko Veselý

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In the treatment of primary insomnia, benzodiazepines and non-benzodiazepine hypnotics are not a first-line medication, mainly due to the dependency risk, especially in longterm treatment. Sedating antidepressants are widely used as an alternative treatment (Wiegand 1999). However, these compounds have several side effects and tend to interact with other(More)
AIMS The prevalence of autoantibodies to zinc transporter 8 (ZnT8) in Czech children at the onset of Type 1 diabetes mellitus and dynamic changes in ZnT8 autoantibody levels during disease progression were studied. The value of ZnT8 autoantibody measurements in diagnosis of Type 1 diabetes was assessed. METHODS Serum samples from 227 children with newly(More)
This is a case report of an 81-year-old man who developed de novo bipolar disorder with ultra-rapid cycling at the age of 80. Mood was self-rated daily over a period of ten weeks; in addition, polysomnographic and motor activity recordings were performed during a drug-free baseline period. Both depressive and hypomanic episodes had an average duration of(More)
The percentage of total T lymphocytes and helper and suppressor cells was determined in the peripheral blood and pleural and abdominal effusions of patients with advanced cancer. The ratio of helper to suppressor cells in the peripheral blood and in the effusions was calculated in each case. The percentage of total T lymphocytes and suppressor cells was(More)
Melatonin is secreted systemically from the pineal gland maximally at night but is also produced locally in many tissues. Its chronobiological function is mainly exerted by pineal melatonin. It is a feedback regulator of the main circadian pacemaker in the hypothalamic suprachiasmatic nuclei and of many peripheral oscillators. Although exogenous melatonin(More)
Early investigations on nocturnal penile tumescence (NPT) reported a close association with REM sleep; later, a less close coupling was observed under certain conditions e.g. in major depression. This supports the hypothesis that partly different mechanisms are involved in the regulation of both phenomena. In the present study, 45 male subjects suffering(More)