Zdenek Zatloukal

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The application of eye drops is known to be problematic due to the high variability of eye drop volume, the low capacity of the precorneal area resulting in an optimal drop volume of about 20 microl, and the risk of adverse systemic effects of drugs due to systemic absorption via the nasal mucosa. While dropper tip design and the surface activity of the(More)
In this work, penetrometry with a sphere was employed to study the flow properties of non-consolidated pharmaceutical powder excipients: sodium chloride, sodium citrate, boric acid, and sorbitol. In order to estimate flow rate, the pressure of penetration in Pascals was used. Penetrometry measurement with a sphere requires modification of the measurement(More)
The application of eye drops from flexible dropper bottles fitted with different types of dropper tips is associated with the high variability of eye drop weights. The aim of this report was to investigate the simultaneous effect of three factors influencing the mean weight of drops dispensing from two plastic dropper tips. Using a designed experiment(More)
Hydration of polyhydroxyethylmethacrylate (PHEMAs hydrogel with aqueous solutions of medicinal substance) renders it possible to deposit medicinal substances within the hydrogel. At the same time the concentration of the medicinal substances in the hydrogel is higher than their concentration in the hydrating solution. For the nonspecific interactions, which(More)
  • Z Zatloukal
  • Ceská a Slovenská farmacie : casopis Ceske…
  • 2000
Using a hydrated filtering membrane, the rate of hydration of the lyophilized xerogel hydroxypropylmethyl cellulose (HPMC) 4000 with an isotonic solution of sodium chloride was examined. The presence of the electrolyte influences the kinetics of diffuse hydration linearized by the root of time. Sodium chloride or pilocarpinium chloride significantly(More)
The influence of the orifice height of a cylindrical, flat-bottomed hopper on the mass flow rate of the free-flowable size fractions of sodium chloride and boric acid was investigated. It was observed that a zone of sudden acceleration of the mass flow under gravity occurred when a critical orifice height had been achieved. Based on the results, an orifice(More)
In this work, the weights of drops produced by seven commercially available eye drop dispensing systems were investigated using benzalkonium chloride solutions in concentration range of 0-0.02%. The effect of the surface tension, the effective diameter of the dropper tip, and the dropper bottle volume on the drop weights was studied at the vertical(More)