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In this work, the weights of drops produced by seven commercially available eye drop dispensing systems were investigated using benzalkonium chloride solutions in concentration range of 0-0.02%. The effect of the surface tension, the effective diameter of the dropper tip, and the dropper bottle volume on the drop weights was studied at the vertical… (More)
The application of eye drops from flexible dropper bottles fitted with different types of dropper tips is associated with the high variability of eye drop weights. The aim of this report was to investigate the simultaneous effect of three factors influencing the mean weight of drops dispensing from two plastic dropper tips. Using a designed experiment… (More)
First-order release kinetics is characterized by a linear dependence of the release rate on the released amount of the active ingredient, the triple of the absolute value of the exponent of the exponential function expressing the reactive fractal dimension DR. Scopolamine bromide release from hydroxypropylmethylcellulose hydrogel was first expressed by… (More)