Zdenek Hruban

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Administration of amphiphilic drugs to experimental animals causes formation of myelinoid bodies in many cell types, accumulation of foamy macrophages in pulmonary alveoli and pulmonary alveolar proteinosis. These changes are the result of an interaction between the drugs and phospholipids which leads to an alteration in physicochemical properties of the(More)
An intracellular process consisting of the sequestration of cytoplasmic components followed by the formation of complex dense bodies, which correspond to the lysosomes of biochemists, is established by ultrastructural studies. This natural process is enhanced by cellular injury. The noxious agent codetermines the structure of the bodies. [The SCI ®(More)
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