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- Roman Zuber, Martin Modrianský, +4 authors Pavel Anzenbacher
- Phytotherapy research : PTR
- 2002

Silybin and related flavonolignans form a major part of the Silybum marianum extract, silymarin, which has been used to treat liver diseases for hundreds of years. Although regarded as safe, many of… (More)

- Lukáš Červený, Lucie Svecova, +6 authors Petr Pávek
- Drug metabolism and disposition: the biological…
- 2007

In our study, we tested the hypothesis whether valproic acid (VPA) in therapeutic concentrations has potential to affect expression of CYP3A4 and MDR1 via constitutive androstane receptor (CAR) and… (More)

- Zdenek Dvorak, Daniel Král, Robin Thomas
- 2010 IEEE 51st Annual Symposium on Foundations of…
- 2010

We present a linear-time algorithm for deciding first-order logic (FOL) properties in classes of graphs with bounded expansion. Many natural classes of graphs have bounded expansion: graphs of… (More)

- Zdenek Dvorak, Daniel Král, Pavel Nejedlý, Riste Skrekovski
- Eur. J. Comb.
- 2008

Wang and Lih conjectured that for every g ≥ 5, there exists a number M(g) such that the square of a planar graph G of girth at least g and maximum degree ∆ ≥ M(g) is (∆+1)-colorable. The conjecture… (More)

- Zdenek Dvorak
- Eur. J. Comb.
- 2013

The k-domination number of a graph is the minimum size of a set X such that every vertex of G is in distance at most k from X. We give a linear time constant-factor approximation algorithm for… (More)

- Jean Marc Pascussi, Zdenek Dvorak, Sabine Gerbal-chaloin, Eric Assénat, Patrick Maurel, Marie José Vilarem
- Drug metabolism reviews
- 2003

The body defends itself against potentially harmful compounds, such as drugs and toxic endogenous compounds and their metabolites, by inducing the expression of enzymes and transporters involved in… (More)

- Lucie Stejskalová, Zdenek Dvorak, Petr Pávek
- Current drug metabolism
- 2011

Aryl hydrocarbon receptor (AhR) is an important transcriptional regulator of drug metabolizing enzymes that dominantly controls the expression of cytochrome P450 CYP1 family genes and some phase II… (More)

- Zdenek Dvorak, Jitka Ulrichová, Martin Modrianský
- Current drug metabolism
- 2005

Superfamily of cytochrome P450 enzymes (CYPs), a distinctive enzyme system by which human body defends itself against toxic compounds, is the subject of a complex regulation process involving various… (More)

- Boris Cvek, Zdenek Dvorak
- Current pharmaceutical design
- 2007

Dithiocarbamates and their complexes with transition metals have been used as common pesticides, vulcanizing or analytical agents for decades. These compounds are one of the most reported inhibitors… (More)

- Petr Pávek, Zdenek Dvorak
- Current drug metabolism
- 2008

Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights into these processes… (More)