Zbylut J. Twardowski

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Longer treatment time (TT) and slower ultrafiltration rate (UFR) are considered advantageous for hemodialysis (HD) patients. The study included 22,000 HD patients from seven countries in the Dialysis Outcomes and Practice Patterns Study (DOPPS). Logistic regression was used to study predictors of TT > 240 min and UFR > 10 ml/h/kg bodyweight. Cox regression(More)
The technique of continuous ambulatory peritoneal dialysis was evaluated in nine patients during 136 patient weeks. The major objectives were to see if continuous ambulatory peritoneal dialysis would provide [1] acceptable control of serum chemistries by usual criteria, [2] adequate removal of sodium and water, [3] tolerable protein losses, and [4] a low(More)
Fast Pet test is a modified version of original PET. Only one dialysate sample for glucose and creatinine is taken from the total drained dialysate and a blood sample at the end of the test exchange. It can be used both for diagnostic and prognostic purposes. The Pet and clearance measurements are complementary studies which can guide in dialysis(More)
Ram Gokal,, Steven Alexander,, Stephen Ash,, Tzen W. Chen,, Anders Danielson,, Cliff Holmes,, Preben Joffe,, Jack Moncrief,, Kirt Nichols,, Beth Piraino,, Barbara Prowant,, Alain Slingeneyer,, Bernd Stegmayr,, Zbylut Twardowski,, Stephen Vas Manchester Royal Infirmary,, Manchester, U.K.; Stanford University Medical Centre,, Stanford, HemoCleanse,, West(More)
The peritoneal catheter is the CAPD patient's lifeline. Advances in catheter knowledge have made it possible to access the peritoneal cavity safely and maintain access over an extended period of time. Infection at the exit site remains a major problem, a solution for which is being extensively researched. The successful outcome of a catheter in an(More)
Peritoneal transport rates, a critical determinant of peritoneal dialysis efficiency, vary widely among patients and may be easily categorized by standardized peritoneal equilibration test. Measurements of creatinine and glucose transfer are particularly useful in selecting optimal dialysis prescription. Patients with high-average peritoneal solute(More)
In the original peritoneal equilibration test (PET), which established standard values for membrane categorization in 1987, the dwell time of the preceding exchange was approximately 8 hours. Basing the test on an 8-hour prior exchange was convenient when almost all patients were on continuous ambulatory peritoneal dialysis (CAPD); however, many patients(More)
The purpose of this paper is to explore the validity of applying urea kinetic indices to CAPD. According to the peak concentration hypothesis, the values of Kt/V required for adequate dialysis are lower for CAPD than for hemodialysis because of the continuous steady state nature of CAPD. Pilot clinical studies were undertaken in 19 patients to correlate the(More)
John Hershey is a 25-year-old man with ESRD secondary to interstitial nephritis. He has a swan-neck, coiled peritoneal dialysis catheter implanted 10 weeks ago and is doing nightly tidal peritoneal dialysis and still has good residual renal function. A week ago John called his primary nurse at the PD clinic to report ‘I think I hurt my exit site. It is red,(More)