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  • Wojciech Gorczyca, J Gong, Zbigniew Darzynkiewicz
  • Biology, Medicine
  • Cancer research
  • 1993 (First Publication: 15 April 1993)
  • DNA strand breaks which occur in HL-60 cells as a result of activation of endonuclease during apoptosis induced by cell treatment with the DNA topoisomerase I inhibitor camptothecin and topoisomeraseExpand
  • Wojciech Gorczyca, J Gong, Barbara Ardelt, Frank Traganos, Zbigniew Darzynkiewicz
  • Biology, Medicine
  • Cancer research
  • 1993 (First Publication: 1 July 1993)
  • The studies were aimed to detect the cell cycle-associated differences in the susceptibility of HL-60 cells to apoptosis induced by diverse agents. Exponentially growing HL-60 cells were treated withExpand
  • Wojciech Gorczyca, Frank Traganos, H Jesionowska, Zbigniew Darzynkiewicz
  • Biology, Medicine
  • Experimental cell research
  • 1993 (First Publication: 1 July 1993)
  • The presence of sperm cells characterized by increased sensitivity of DNA in situ to denaturation and by abnormal morphology (shape) in semen is associated with low fertility. Such cells often appearExpand
  • Elzbieta Bedner, Piotr Smolewski, Paul Dr Amstad, Zbigniew Darzynkiewicz
  • Biology, Medicine
  • Experimental cell research
  • 2000 (First Publication: 1 August 2000)
  • Activation of caspases is the key event of apoptosis and new methods are needed to assay this event, particularly in situ, in individual cells. To measure in situ caspases activation in the presentExpand